{"id":15121,"date":"2026-02-13T16:11:25","date_gmt":"2026-02-13T15:11:25","guid":{"rendered":"https:\/\/www.cbd.fr\/blog\/?p=15121"},"modified":"2026-02-13T16:11:27","modified_gmt":"2026-02-13T15:11:27","slug":"anxiety-distinguishing-between-animal-and-human-studies-on-cbd","status":"publish","type":"post","link":"https:\/\/www.cbd.fr\/blog\/anxiety-distinguishing-between-animal-and-human-studies-on-cbd\/","title":{"rendered":"Anxiety: Distinguishing between animal and human studies on CBD"},"content":{"rendered":"<p><strong>Cannabidiol, better known by its acronym CBD, is generating increasing interest in the fight against anxiety disorders. Many tout its anxiolytic effects, but ambiguity remains regarding the relevance of results obtained in animal studies compared to data from human studies. Understanding how these studies differ is essential for refining the discourse surrounding CBD and anxiety, and for truly assessing its impact on mental health. Why differentiate between animal and human studies? The question of the transferability of results from animal studies to humans regularly arises in the field of cannabidiol (CBD). Researchers primarily use rodents to model the functioning of the endocannabinoid system, which is responsible for regulating many functions related to stress and mood. Despite significant biological similarities, certain neurobiological mechanisms vary between species, complicating the extrapolation of effects observed in animals to humans.<\/strong> <strong>The clinical application of CBD in patients with anxiety disorders thus depends on reliable evidence reproduced under conditions similar to those observed in humans. Many promising results from animal experiments have not been fully confirmed by robust clinical trials. Making this distinction remains crucial before drawing general conclusions about the anxiolytic effects of CBD.<\/strong> <strong>Methodologies: What are the differences between animal and human studies?<\/strong>The experimental protocols used in evaluating CBD and anxiety differ considerably depending on whether the study is conducted on animals or humans. These distinctions strongly influence the types of data collected and their interpretation. <strong>To discover how CBD specifically affects anxiety and what its main recognized benefits are, it can be helpful to examine its effects as observed in different contexts. The article on the<\/strong>anxiolytic properties of CBD<strong>details in particular the observed impacts on chronic and acute anxiety.<\/strong> <strong>Design and conduct of animal studies<\/strong>Animal studies <strong>often involve specific models, such as mice subjected to stimuli that generate a<\/strong>measurable state of anxiety <strong>. Researchers then evaluate different behaviors, such as immobility, hiding, or reactions to novelty, after administration of<\/strong>cannabidiol<\/p>\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Sommaire<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #43b981;color:#43b981\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #43b981;color:#43b981\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.cbd.fr\/blog\/anxiety-distinguishing-between-animal-and-human-studies-on-cbd\/#_This_approach_allows_for_precise_control_of_the_environment_and_the_parameters_studied\" >. This approach allows for precise control of the environment and the parameters studied.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.cbd.fr\/blog\/anxiety-distinguishing-between-animal-and-human-studies-on-cbd\/#compared_to_human_complexity\" >compared to human complexity<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.cbd.fr\/blog\/anxiety-distinguishing-between-animal-and-human-studies-on-cbd\/#depending_on_the_study_design_and_the_population_tested\" >depending on the study design and the population tested.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.cbd.fr\/blog\/anxiety-distinguishing-between-animal-and-human-studies-on-cbd\/#were_observed_after_acute_use\" >were observed after acute use.<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.cbd.fr\/blog\/anxiety-distinguishing-between-animal-and-human-studies-on-cbd\/#psychiatric_history\" >psychiatric history,<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.cbd.fr\/blog\/anxiety-distinguishing-between-animal-and-human-studies-on-cbd\/#Study_duration\" >Study duration<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.cbd.fr\/blog\/anxiety-distinguishing-between-animal-and-human-studies-on-cbd\/#Multiple_contextual_factors_and_medical_history\" >Multiple contextual factors and medical history<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.cbd.fr\/blog\/anxiety-distinguishing-between-animal-and-human-studies-on-cbd\/#There_is_currently_no_one-size-fits-all_solution_each_person_must_tailor_their_approach_to_their_individual_needs_and_receive_clear_information_about_the_limitations_of\" >There is currently no one-size-fits-all solution; each person must tailor their approach to their individual needs and receive clear information about the limitations of<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"_This_approach_allows_for_precise_control_of_the_environment_and_the_parameters_studied\"><\/span>. This approach allows for precise control of the environment and the parameters studied.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>However, transposing these <strong>artificially induced states of anxiety<\/strong> to human experience remains challenging. An animal&#8217;s behavioral responses only partially reflect the complexity of the <strong>emotions<\/strong>and thoughts associated with <strong>anxiety in humans<\/strong>. Framework of Human Clinical Studies <strong>In humans, anxiety disorders are assessed using standardized questionnaires, brain imaging, and physiological markers such as heart rate. Participants receive varying doses of CBD to observe changes in symptoms or performance on certain social or cognitive tasks.<\/strong> There is a consensus among healthcare professionals regarding the growing interest in CBD across various therapeutic approaches, although ideal doses still need to be defined for each individual case.<strong>Results of Animal Studies: What Lessons for CBD and Anxiety?<\/strong>The results from animal studies generally show a positive trend regarding the use of cannabidiol in reducing anxiety symptoms. <strong>This research highlights specific mechanisms of action on the endocannabinoid system that appear to be modulated by CBD.<\/strong>  <strong>Furthermore, recent publications also detail the beneficial effects of CBD oil for managing anxiety, as explained in this comprehensive article on the positive effects of CBD on anxiety.<\/strong><\/p>\n<p>Identified Mechanisms and Receptor Modulation: In animals, CBD administration activates certain specific receptors involved in stress management, primarily CB1, CB2, and 5-HT1A receptors. This activation contributes to a noticeable reduction in anxious behavior observed in various behavioral tests. <strong>Experiments are also expanding our understanding of CBD&#8217;s role as an indirect modulator, balancing other neurotransmitters important in the stress response. The identification of these molecular targets fuels hope that the anxiolytic effects may be applicable to humans, although this hypothesis requires confirmation.<\/strong> Limitations in the interpretation of animal data<strong>Despite encouraging indications, several biases exist in these tests:<\/strong> species used, method of CBD administration, and highly controlled environment. Added to this is the absence of reflective awareness of stress in animals, which reduces the scope of observations made on these models. <strong><\/strong>Furthermore, most animal studies do not incorporate the chronic or psychosocial dimension of anxiety experienced over the long term in humans. This necessitates caution in generalizing these results, despite the avenues of research opened up. <strong><\/strong>Simplicity of observed behaviors<\/p>\n\n<h2><span class=\"ez-toc-section\" id=\"compared_to_human_complexity\"><\/span>compared to human complexity<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Difficult transition from the acute model to the chronic dimension <strong>Metabolic differences between species<\/strong> regarding CBD assimilation <strong>Major trends emerging from human studies on CBD and anxiety<\/strong> While the<strong>Animal experiments<\/strong>shed light on certain mechanisms, while <strong>human studies<\/strong> offer a contrasting picture of the<\/p>\n<p>effects of CBD on mental health. <a href=\"https:\/\/www.cbd.fr\/blog\/lhuile-de-cbd-aide-t-elle-votre-anxiete\/\">Although benefits have sometimes been reported, they manifest with<\/a> notable heterogeneity<\/p>\n\n<h3><span class=\"ez-toc-section\" id=\"depending_on_the_study_design_and_the_population_tested\"><\/span>depending on the study design and the population tested.<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>This variability underscores the importance of continuing <strong>clinical research<\/strong> and refining evaluation methods to better understand the true impact of <strong>cannabidiol<\/strong>on human <strong>anxiety disorders.<\/strong>Data from early clinical trials<\/p>\n<p>Some trials suggest that <strong>moderate doses of cannabidiol<\/strong> may reduce <strong>anxiety experienced during occasional stressful situations,<\/strong> <strong>such as public speaking. Reduced scores on<\/strong>subjective anxiety rating scales<\/p>\n\n<h3><span class=\"ez-toc-section\" id=\"were_observed_after_acute_use\"><\/span>were observed after acute use.<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p> <strong>However, most protocols include a small number of participants and do not always employ rigorous double-blind or placebo-controlled methods. A<\/strong> significant placebo effect <strong>then obscures the results, necessitating further investigations on a larger scale.<\/strong> <strong>Methodological Needs and Perspectives<\/strong> The scientific community emphasizes the need to expand<\/p>\n<p>cohorts, lengthen follow-up periods, and better control confounding factors. These variables include, in particular,<\/p>\n\n<h2><span class=\"ez-toc-section\" id=\"psychiatric_history\"><\/span>psychiatric history,<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>the quality of the cannabidiol extracts used, <strong>and the potential simultaneous use of other medications or therapies.<\/strong>  <strong>A specific challenge lies in the variety of<\/strong> anxiety disorders considered\u2014social phobias, generalized anxiety, panic disorder\u2014which may respond differently to treatment. No consensus has yet been reached on the <strong>optimal target population<\/strong>or on the <strong>appropriate dosages<\/strong> to achieve a significant therapeutic effect. <strong><\/strong> Criteria <strong>Animal Studies<\/strong>Human Studies<\/p>\n<p>Typical Dose <a href=\"https:\/\/www.cbd.fr\/blog\/lhuile-de-cbd-aide-t-elle-votre-anxiete\/\">Low to very high<\/a>Moderate to high, variable<\/p>\n\n<h3><span class=\"ez-toc-section\" id=\"Study_duration\"><\/span>Study duration<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Short term <strong>Short to medium term<\/strong> Measurement type <strong>Observed behaviors<\/strong> Self-reported symptoms, biomarkers <strong>Transposability<\/strong>Limited <strong>High, but more complex<\/strong> Frequently asked questions about CBD, anxiety, and study types <strong>What are the main advantages of animal studies on CBD and anxiety?<\/strong>Strict control of variables (dose, environment) <strong>Direct observation of effects on animals<\/strong> Detailed understanding of the mechanisms of the endocannabinoid system<\/p>\n<p>These animal studies allow researchers to test complex hypotheses about the anxiolytic effects of cannabidiol, while avoiding some ethical risks associated with clinical research in humans. <strong>Why are the effects of CBD observed in animals not always observed in humans? Metabolic, genetic, and behavioral differences explain a significant portion of the variability. Psychological experiences, personal history, and stress perception make each human case unique. In animals, some reaction patterns remain basic, far removed from human emotional complexity.<\/strong> <strong>High interindividual variability in humans<\/strong> Placebo effect often stronger in humans<\/p>\n\n<h3><span class=\"ez-toc-section\" id=\"Multiple_contextual_factors_and_medical_history\"><\/span>Multiple contextual factors and medical history<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Are there risks in extrapolating the results of animal studies on CBD to human anxiety disorders? <strong><\/strong>Yes, because this type of extrapolation can mask specificities related to the human species, such as the psychological response, long-term tolerance, and potential drug interactions. This can lead to inappropriate recommendations and false hopes for people suffering from anxiety. <strong>Overinterpretation of potential benefits<\/strong>Ignorance of human-specific side effects<\/p>\n<p>Risk of delaying appropriate medical research <strong>What precautions should you take before using CBD for anxiety disorders?<\/strong> Consult a healthcare professional<strong>for personalized guidance.<\/strong> Start with low doses<\/p>\n<ul>\n\t<li><strong>while monitoring your individual reaction.<\/strong> Choose cannabidiol products<\/li>\n\t<li><strong>whose content has been verified by independent testing.<\/strong><\/li>\n\t<li><strong>Consider potential interactions<\/strong> with other treatments or illnesses.<\/li>\n<\/ul>\n\n<h2><span class=\"ez-toc-section\" id=\"There_is_currently_no_one-size-fits-all_solution_each_person_must_tailor_their_approach_to_their_individual_needs_and_receive_clear_information_about_the_limitations_of\"><\/span>There is currently no one-size-fits-all solution; each person must tailor their approach to their individual needs and receive clear information about the limitations of<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>existing studies <strong>.<\/strong>  <strong><\/strong>  <strong><\/strong> <strong><\/strong> <\/p>\n<p> <strong><\/strong>  <strong><\/strong>  <strong><\/strong> <\/p>\n\n<h3><\/h3>\n<p> <strong><\/strong> <strong><\/strong> <strong><\/strong> <\/p>\n<p> <strong><\/strong> <\/p>\n\n<h3><\/h3>\n<p> <strong><\/strong> <strong><\/strong> <strong><\/strong><\/p>\n<p> <strong><\/strong>  <strong><\/strong>  <strong><\/strong> <\/p>\n\n<table>\n\t<tr>\n\t\t<th><\/th>\n\t\t<th><\/th>\n\t\t<th><\/th>\n\t<\/tr>\n\t<tr>\n\t\t<td><strong><\/strong><\/td>\n\t\t<td><\/td>\n\t\t<td><\/td>\n\t<\/tr>\n\t<tr>\n\t\t<td><strong><\/strong><\/td>\n\t\t<td><\/td>\n\t\t<td><\/td>\n\t<\/tr>\n\t<tr>\n\t\t<td><strong><\/strong><\/td>\n\t\t<td><\/td>\n\t\t<td><\/td>\n\t<\/tr>\n\t<tr>\n\t\t<td><strong><\/strong><\/td>\n\t\t<td><\/td>\n\t\t<td><\/td>\n\t<\/tr>\n<\/table>\n\n<h2><\/h2>\n\n<div>\n  <div>\n    <h3><\/h3>\n    <div>\n      <div>\n        <ul>\n          <li><strong><\/strong> <\/li>\n          <li><strong><\/strong><\/li>\n          <li><strong><\/strong><\/li>\n        <\/ul>\n        <p> <strong><\/strong>  <strong><\/strong><\/p>\n      <\/div>\n    <\/div>\n  <\/div>\n  <div>\n    <h3><\/h3>\n    <div>\n      <div>\n        <p> <strong><\/strong><\/p>\n        <ul>\n          <li><strong><\/strong><\/li>\n          <li><strong><\/strong><\/li>\n          <li><strong><\/strong><\/li>\n        <\/ul>\n      <\/div>\n    <\/div>\n  <\/div>\n  <div>\n    <h3><\/h3>\n    <div>\n      <div>\n        <p> <strong><\/strong><strong><\/strong><\/p>\n        <ul>\n          <li><strong><\/strong><\/li>\n          <li><strong><\/strong><\/li>\n          <li><strong><\/strong><\/li>\n        <\/ul>\n      <\/div>\n    <\/div>\n  <\/div>\n  <div>\n    <h3><\/h3>\n    <div>\n      <div>\n        <ol>\n          <li><strong><\/strong> <\/li>\n          <li><strong><\/strong> <\/li>\n          <li><strong><\/strong> <\/li>\n          <li><strong><\/strong> <\/li>\n        <\/ol>\n        <p> <strong><\/strong><\/p>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/div>\n\n\n\n<div class=\"kk-star-ratings kksr-auto kksr-align-left kksr-valign-bottom\"\n    data-payload='{&quot;align&quot;:&quot;left&quot;,&quot;id&quot;:&quot;15121&quot;,&quot;slug&quot;:&quot;default&quot;,&quot;valign&quot;:&quot;bottom&quot;,&quot;ignore&quot;:&quot;&quot;,&quot;reference&quot;:&quot;auto&quot;,&quot;class&quot;:&quot;&quot;,&quot;count&quot;:&quot;0&quot;,&quot;legendonly&quot;:&quot;&quot;,&quot;readonly&quot;:&quot;&quot;,&quot;score&quot;:&quot;0&quot;,&quot;starsonly&quot;:&quot;&quot;,&quot;best&quot;:&quot;5&quot;,&quot;gap&quot;:&quot;5&quot;,&quot;greet&quot;:&quot;Notez cet article&quot;,&quot;legend&quot;:&quot;0\\\/5 - (0 vote)&quot;,&quot;size&quot;:&quot;24&quot;,&quot;title&quot;:&quot;Anxiety: Distinguishing between animal and human studies on CBD&quot;,&quot;width&quot;:&quot;0&quot;,&quot;_legend&quot;:&quot;{score}\\\/{best} - ({count} {votes})&quot;,&quot;font_factor&quot;:&quot;1.25&quot;}'>\n            \n<div class=\"kksr-stars\">\n    \n<div class=\"kksr-stars-inactive\">\n            <div class=\"kksr-star\" data-star=\"1\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; 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Many tout its anxiolytic effects, but ambiguity remains regarding the relevance of results obtained in animal studies compared to data from human studies. Understanding how these studies differ is essential for refining the discourse surrounding CBD and anxiety, [&hellip;]<\/p>\n","protected":false},"author":90,"featured_media":13873,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_sitemap_exclude":false,"_sitemap_priority":"","_sitemap_frequency":"","footnotes":""},"categories":[1019],"tags":[],"class_list":["post-15121","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-around-the-cbd-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Anxiety: Distinguishing between animal and human studies on CBD - CBD Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cbd.fr\/blog\/anxiety-distinguishing-between-animal-and-human-studies-on-cbd\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\ud83c\udf31Anxiety: Distinguishing between animal and human studies on CBD - CBD.fr \ud83c\udf31\" \/>\n<meta property=\"og:description\" content=\"Cannabidiol, better known by its acronym CBD, is generating increasing interest in the fight against anxiety disorders. 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Understanding how these studies differ is essential for refining the discourse surrounding CBD and anxiety, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cbd.fr\/blog\/anxiety-distinguishing-between-animal-and-human-studies-on-cbd\/\" \/>\n<meta property=\"og:site_name\" content=\"CBD Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/cbdfrr\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-13T15:11:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-13T15:11:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cbd.fr\/blog\/wp-content\/uploads\/2025\/08\/anxi_t_distinguer_tudes_animales_et_tudes_humaines_sur_le_cbd.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1344\" \/>\n\t<meta property=\"og:image:height\" content=\"768\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Julien\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Julien\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Anxiety: Distinguishing between animal and human studies on CBD - CBD Blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cbd.fr\/blog\/anxiety-distinguishing-between-animal-and-human-studies-on-cbd\/","og_locale":"fr_FR","og_type":"article","og_title":"\ud83c\udf31Anxiety: Distinguishing between animal and human studies on CBD - CBD.fr \ud83c\udf31","og_description":"Cannabidiol, better known by its acronym CBD, is generating increasing interest in the fight against anxiety disorders. 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