{"id":17029,"date":"2026-02-13T17:15:38","date_gmt":"2026-02-13T16:15:38","guid":{"rendered":"https:\/\/www.cbd.fr\/blog\/?p=17029"},"modified":"2026-02-13T17:15:39","modified_gmt":"2026-02-13T16:15:39","slug":"understanding-the-interactions-between-cbd-and-sitagliptin","status":"publish","type":"post","link":"https:\/\/www.cbd.fr\/blog\/understanding-the-interactions-between-cbd-and-sitagliptin\/","title":{"rendered":"Understanding the interactions between CBD and Sitagliptin"},"content":{"rendered":"<p>Cannabidiol (CBD) is increasingly popular for its potential therapeutic properties. But before using it in conjunction with other medications, it&#8217;s essential to understand how it might interact with them. In this article, we&#8217;ll examine the potential interactions between CBD and sitagliptin, a medication commonly used to treat type 2 diabetes. The medications in question include Januvia and Xelevia.<\/p>\n<h2><\/h2>\n<p>Sitagliptin: An Effective Treatment for Type 2 Diabetes<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Sommaire<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #43b981;color:#43b981\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #43b981;color:#43b981\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.cbd.fr\/blog\/understanding-the-interactions-between-cbd-and-sitagliptin\/#Sitagliptin_is_an_oral_medication_that_doctors_typically_prescribe_to_people_with_type_2_diabetes_It_belongs_to_the_class_of_DPP-4_inhibitors_which_work_by_blocking_the_action_of_an_enzyme_called_dipeptidyl_peptidase-4_This_inhibition_allows_the_body_to_produce_more_insulin_and_lower_blood_sugar_levels_Sitagliptin_is_often_prescribed_in_tablet_form_such_as_Januvia_and_Xelevia\" >Sitagliptin is an oral medication that doctors typically prescribe to people with type 2 diabetes. It belongs to the class of DPP-4 inhibitors, which work by blocking the action of an enzyme called dipeptidyl peptidase-4. This inhibition allows the body to produce more insulin and lower blood sugar levels. Sitagliptin is often prescribed in tablet form, such as Januvia and Xelevia.<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.cbd.fr\/blog\/understanding-the-interactions-between-cbd-and-sitagliptin\/#CBD_A_Natural_Alternative_for_Relieving_Certain_Conditions\" >CBD: A Natural Alternative for Relieving Certain Conditions<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.cbd.fr\/blog\/understanding-the-interactions-between-cbd-and-sitagliptin\/#Potential_Effects_of_CBD_on_Diabetes\" >Potential Effects of CBD on Diabetes<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.cbd.fr\/blog\/understanding-the-interactions-between-cbd-and-sitagliptin\/#Potential_Interactions_Between_CBD_and_Sitagliptin\" >Potential Interactions Between CBD and Sitagliptin<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.cbd.fr\/blog\/understanding-the-interactions-between-cbd-and-sitagliptin\/#If_you_are_considering_taking_CBD_in_addition_to_your_sitagliptin_treatment_it_is_essential_to_consult_a_healthcare_professional_They_can_help_you_determine_if_this_combination_is_safe_for_you_and_advise_you_on_the_appropriate_dosage\" >If you are considering taking CBD in addition to your sitagliptin treatment, it is essential to consult a healthcare professional. They can help you determine if this combination is safe for you and advise you on the appropriate dosage.<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Sitagliptin_is_an_oral_medication_that_doctors_typically_prescribe_to_people_with_type_2_diabetes_It_belongs_to_the_class_of_DPP-4_inhibitors_which_work_by_blocking_the_action_of_an_enzyme_called_dipeptidyl_peptidase-4_This_inhibition_allows_the_body_to_produce_more_insulin_and_lower_blood_sugar_levels_Sitagliptin_is_often_prescribed_in_tablet_form_such_as_Januvia_and_Xelevia\"><\/span>Sitagliptin is an oral medication that doctors typically prescribe to people with type 2 diabetes. It belongs to the class of DPP-4 inhibitors, which work by blocking the action of an enzyme called dipeptidyl peptidase-4. This inhibition allows the body to produce more insulin and lower blood sugar levels. Sitagliptin is often prescribed in tablet form, such as Januvia and Xelevia. <span class=\"ez-toc-section-end\"><\/span><\/h2>\n<\/p>\n<h3><span class=\"ez-toc-section\" id=\"CBD_A_Natural_Alternative_for_Relieving_Certain_Conditions\"><\/span>CBD: A Natural Alternative for Relieving Certain Conditions<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Cannabidiol, or CBD, is a non-psychoactive compound found in the cannabis plant. It has gained popularity in recent years due to its therapeutic potential for a wide range of conditions, including anxiety, chronic pain, and epilepsy. CBD can be consumed in the form of tinctures, <a href=\"https:\/\/www.cbd.fr\/173gelules-cbd\" data-internallinksmanager029f6b8e52c=\"8\" title=\"G\u00e9lule CBD\">capsules<\/a>, edibles, or applied topically to the skin.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Potential_Effects_of_CBD_on_Diabetes\"><\/span>Potential Effects of CBD on Diabetes<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There is some evidence suggesting that CBD may have beneficial effects on managing diabetes. Studies have shown that CBD may help reduce inflammation, protect insulin-producing cells, and promote their survival. Furthermore, CBD has also been associated with improved insulin sensitivity and reduced insulin resistance. <\/p>\n<h3><span class=\"ez-toc-section\" id=\"Potential_Interactions_Between_CBD_and_Sitagliptin\"><\/span>Potential Interactions Between CBD and Sitagliptin<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>It is important to discuss with your healthcare professional before combining CBD with sitagliptin or any other diabetes medication. As with any drug interaction, the effects can vary depending on the individual and their specific medical conditions.<\/p>\n<p> <strong>Enzyme Inhibition and Metabolism<\/strong> Both CBD and sitagliptin are metabolized by the liver. CBD can inhibit certain enzymes responsible for drug metabolism, particularly CYP3A4 and CYP2C19. Sitagliptin is primarily metabolized by CYP3A4. Therefore, combining these substances could theoretically lead to decreased sitagliptin metabolism and increased blood concentration. <\/p>\n<h3><\/h3>\n<p>This means that if you take CBD with sitagliptin, your body may not metabolize the latter medication as efficiently. This could potentially lead to a stronger or longer-lasting effect of the medication, thus increasing the risk of unwanted side effects. Potential for Hypoglycemia<\/p>\n<p>Another concern regarding the interaction between CBD and sitagliptin is the possibility of hypoglycemia, meaning a dangerously low blood sugar level. CBD can improve insulin sensitivity and reduce insulin resistance, while sitagliptin promotes insulin production. <strong>Therefore, there is a potential, albeit limited, risk that their combination could lead to a dangerously low blood glucose level in some individuals. In severe cases, hypoglycemia can cause fainting, seizures, and even coma.<\/strong>Precautions to take when using CBD and sitagliptin together.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"If_you_are_considering_taking_CBD_in_addition_to_your_sitagliptin_treatment_it_is_essential_to_consult_a_healthcare_professional_They_can_help_you_determine_if_this_combination_is_safe_for_you_and_advise_you_on_the_appropriate_dosage\"><\/span>If you are considering taking CBD in addition to your sitagliptin treatment, it is essential to consult a healthcare professional. They can help you determine if this combination is safe for you and advise you on the appropriate dosage.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<\/p>\n<p>Furthermore, it is crucial to carefully monitor your blood sugar levels when using CBD and sitagliptin together, as this will allow for dose adjustments and minimize the risk of hypoglycemia or other complications.<\/p>\n\n\n<div class=\"kk-star-ratings kksr-auto kksr-align-left kksr-valign-bottom\"\n    data-payload='{&quot;align&quot;:&quot;left&quot;,&quot;id&quot;:&quot;17029&quot;,&quot;slug&quot;:&quot;default&quot;,&quot;valign&quot;:&quot;bottom&quot;,&quot;ignore&quot;:&quot;&quot;,&quot;reference&quot;:&quot;auto&quot;,&quot;class&quot;:&quot;&quot;,&quot;count&quot;:&quot;0&quot;,&quot;legendonly&quot;:&quot;&quot;,&quot;readonly&quot;:&quot;&quot;,&quot;score&quot;:&quot;0&quot;,&quot;starsonly&quot;:&quot;&quot;,&quot;best&quot;:&quot;5&quot;,&quot;gap&quot;:&quot;5&quot;,&quot;greet&quot;:&quot;Notez cet article&quot;,&quot;legend&quot;:&quot;0\\\/5 - (0 vote)&quot;,&quot;size&quot;:&quot;24&quot;,&quot;title&quot;:&quot;Understanding the interactions between CBD and Sitagliptin&quot;,&quot;width&quot;:&quot;0&quot;,&quot;_legend&quot;:&quot;{score}\\\/{best} - ({count} {votes})&quot;,&quot;font_factor&quot;:&quot;1.25&quot;}'>\n            \n<div class=\"kksr-stars\">\n    \n<div class=\"kksr-stars-inactive\">\n            <div class=\"kksr-star\" data-star=\"1\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"2\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"3\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"4\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"5\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n    <\/div>\n    \n<div class=\"kksr-stars-active\" style=\"width: 0px;\">\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n    <\/div>\n<\/div>\n                \n\n<div class=\"kksr-legend\" style=\"font-size: 19.2px;\">\n            <span class=\"kksr-muted\">Notez cet article<\/span>\n    <\/div>\n    <\/div>\n","protected":false},"excerpt":{"rendered":"<p>Cannabidiol (CBD) is increasingly popular for its potential therapeutic properties. But before using it in conjunction with other medications, it&#8217;s essential to understand how it might interact with them. In this article, we&#8217;ll examine the potential interactions between CBD and sitagliptin, a medication commonly used to treat type 2 diabetes. The medications in question include [&hellip;]<\/p>\n","protected":false},"author":90,"featured_media":12072,"comment_status":"closed","ping_status":"open","sticky":false,"template":"default\n","format":"standard","meta":{"_sitemap_exclude":false,"_sitemap_priority":"","_sitemap_frequency":"","footnotes":""},"categories":[999],"tags":[],"class_list":["post-17029","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sante-et-cbd-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Understanding the interactions between CBD and Sitagliptin - CBD Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cbd.fr\/blog\/en\/understanding-the-interactions-between-cbd-and-sitagliptin\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\ud83c\udf31Understanding the interactions between CBD and Sitagliptin - CBD.fr \ud83c\udf31\" \/>\n<meta property=\"og:description\" content=\"Cannabidiol (CBD) is increasingly popular for its potential therapeutic properties. 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The medications in question include [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cbd.fr\/blog\/en\/understanding-the-interactions-between-cbd-and-sitagliptin\/\" \/>\n<meta property=\"og:site_name\" content=\"CBD Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/cbdfrr\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-13T16:15:38+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-13T16:15:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cbd.fr\/blog\/wp-content\/uploads\/2024\/03\/comprendre-les-interactions-entre-le-cbd-et-la-sitagliptine.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1456\" \/>\n\t<meta property=\"og:image:height\" content=\"832\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Julien\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Julien\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Understanding the interactions between CBD and Sitagliptin - CBD Blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cbd.fr\/blog\/en\/understanding-the-interactions-between-cbd-and-sitagliptin\/","og_locale":"fr_FR","og_type":"article","og_title":"\ud83c\udf31Understanding the interactions between CBD and Sitagliptin - CBD.fr \ud83c\udf31","og_description":"Cannabidiol (CBD) is increasingly popular for its potential therapeutic properties. 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The medications in question include [&hellip;]","og_url":"https:\/\/www.cbd.fr\/blog\/en\/understanding-the-interactions-between-cbd-and-sitagliptin\/","og_site_name":"CBD Blog","article_publisher":"https:\/\/www.facebook.com\/cbdfrr\/","article_published_time":"2026-02-13T16:15:38+00:00","article_modified_time":"2026-02-13T16:15:39+00:00","og_image":[{"width":1456,"height":832,"url":"https:\/\/www.cbd.fr\/blog\/wp-content\/uploads\/2024\/03\/comprendre-les-interactions-entre-le-cbd-et-la-sitagliptine.jpg","type":"image\/jpeg"}],"author":"Julien","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"Julien","Dur\u00e9e de lecture estim\u00e9e":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.cbd.fr\/blog\/en\/understanding-the-interactions-between-cbd-and-sitagliptin\/#article","isPartOf":{"@id":"https:\/\/www.cbd.fr\/blog\/en\/understanding-the-interactions-between-cbd-and-sitagliptin\/"},"author":{"name":"Julien","@id":"https:\/\/www.cbd.fr\/blog\/#\/schema\/person\/d78b472d184ec8ae4135d454e3338c04"},"headline":"Understanding the interactions between CBD and Sitagliptin","datePublished":"2026-02-13T16:15:38+00:00","dateModified":"2026-02-13T16:15:39+00:00","mainEntityOfPage":{"@id":"https:\/\/www.cbd.fr\/blog\/en\/understanding-the-interactions-between-cbd-and-sitagliptin\/"},"wordCount":528,"publisher":{"@id":"https:\/\/www.cbd.fr\/blog\/#organization"},"image":{"@id":"https:\/\/www.cbd.fr\/blog\/en\/understanding-the-interactions-between-cbd-and-sitagliptin\/#primaryimage"},"thumbnailUrl":"https:\/\/www.cbd.fr\/blog\/wp-content\/uploads\/2024\/03\/comprendre-les-interactions-entre-le-cbd-et-la-sitagliptine.jpg","articleSection":["Sant\u00e9 et CBD"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/www.cbd.fr\/blog\/en\/understanding-the-interactions-between-cbd-and-sitagliptin\/","url":"https:\/\/www.cbd.fr\/blog\/en\/understanding-the-interactions-between-cbd-and-sitagliptin\/","name":"Understanding the interactions between CBD and Sitagliptin - 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Expertise, qualit\u00e9 et p\u00e9dagogie sont au c\u0153ur de l\u2019exp\u00e9rience CBD.fr.","email":"support@cbd.fr","telephone":"0189720196","legalName":"CBD.fr","foundingDate":"2021-01-01","taxID":"760933","numberOfEmployees":{"@type":"QuantitativeValue","minValue":"11","maxValue":"50"}},{"@type":"Person","@id":"https:\/\/www.cbd.fr\/blog\/#\/schema\/person\/d78b472d184ec8ae4135d454e3338c04","name":"Julien","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/secure.gravatar.com\/avatar\/58f2f1b1e71c329d0226efe2cc40174640e1757e077dac013c980f3ee43c73a0?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/58f2f1b1e71c329d0226efe2cc40174640e1757e077dac013c980f3ee43c73a0?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/58f2f1b1e71c329d0226efe2cc40174640e1757e077dac013c980f3ee43c73a0?s=96&d=mm&r=g","caption":"Julien"},"description":"R\u00e9dacteur en chef sp\u00e9cialis\u00e9 en CBD Julien, n\u00e9 le 17 juillet 1978 en r\u00e9gion Parisienne, est un \u00e9minent r\u00e9dacteur et expert dans le domaine des produits \u00e0 base de CBD. Suite \u00e0 ses \u00e9tudes, Julien a d\u00e9velopp\u00e9 une passion pour les rem\u00e8des naturels, dont le CBD. En 2022, il int\u00e8gre l\u2019\u00e9quipe du site CBD.fr en qualit\u00e9 d\u2019expert et de contributeur r\u00e9gulier. 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