{"id":17372,"date":"2026-02-13T17:27:36","date_gmt":"2026-02-13T16:27:36","guid":{"rendered":"https:\/\/www.cbd.fr\/blog\/?p=17372"},"modified":"2026-02-13T17:27:37","modified_gmt":"2026-02-13T16:27:37","slug":"interactions-between-cbd-and-metoprolol-what-you-need-to-know","status":"publish","type":"post","link":"https:\/\/www.cbd.fr\/blog\/en\/interactions-between-cbd-and-metoprolol-what-you-need-to-know\/","title":{"rendered":"Interactions between CBD and Metoprolol: what you need to know"},"content":{"rendered":"<p>CBD (cannabidiol) is increasingly popular for its numerous health benefits. However, it is essential to be well-informed about potential interactions with other medications, particularly metoprolol. In this article, we will discuss the different characteristics of CBD and metoprolol, as well as their possible interactions. <strong>What is CBD?<\/strong> Cannabidiol (CBD) is a compound extracted from the cannabis plant. Unlike <a href=\"https:\/\/www.cbd.fr\/198thccbd\" data-internallinksmanager029f6b8e52c=\"17\" title=\"thc - t\u00e9trahydrocannabinol\">THC<\/a>, the other major component of cannabis, CBD does not produce psychoactive effects and therefore does not induce a &#8220;high.&#8221; It acts primarily on the body&#8217;s endocannabinoid system, regulating various physiological processes such as pain, anxiety, and sleep.<\/p>\n<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Sommaire<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #43b981;color:#43b981\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #43b981;color:#43b981\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.cbd.fr\/blog\/en\/interactions-between-cbd-and-metoprolol-what-you-need-to-know\/#Numerous_studies_have_highlighted_the_therapeutic_properties_of_CBD_such_as_its_anti-inflammatory_and_antioxidant_effects_its_ability_to_reduce_stress_anxiety_and_even_some_forms_of_epilepsy_It_has_also_demonstrated_cardiovascular_protective_effects_in_some_preclinical_studies\" >Numerous studies have highlighted the therapeutic properties of CBD, such as its anti-inflammatory and antioxidant effects, its ability to reduce stress, anxiety, and even some forms of epilepsy. It has also demonstrated cardiovascular protective effects in some preclinical studies.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.cbd.fr\/blog\/en\/interactions-between-cbd-and-metoprolol-what-you-need-to-know\/#Lopressor_Toprol-XL_Beloc-Zok_and_Metohexal\" >Lopressor, Toprol-XL, Beloc-Zok, and Metohexal.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.cbd.fr\/blog\/en\/interactions-between-cbd-and-metoprolol-what-you-need-to-know\/#It_is_important_to_note_that_there_is_currently_no_robust_clinical_data_regarding_potential_specific_interactions_between_CBD_and_metoprolol\" >It is important to note that there is currently no robust clinical data regarding potential specific interactions between CBD and metoprolol.<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.cbd.fr\/blog\/en\/interactions-between-cbd-and-metoprolol-what-you-need-to-know\/#However_some_studies_have_highlighted_CBDs_potential_to_inhibit_a_liver_enzyme_called_cytochrome_P450_CYP450_which_is_responsible_for_metabolizing_approximately_60_of_medications_available_on_the_market_including_metoprolol\" >However, some studies have highlighted CBD&#8217;s potential to inhibit a liver enzyme called cytochrome P450 (CYP450), which is responsible for metabolizing approximately 60% of medications available on the market, including metoprolol.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.cbd.fr\/blog\/en\/interactions-between-cbd-and-metoprolol-what-you-need-to-know\/#As_mentioned_previously_some_preclinical_research_has_demonstrated_a_cardiovascular_protective_effect_of_CBD_While_this_may_seem_beneficial_at_first_it_is_difficult_to_assess_without_reliable_clinical_data_whether_this_interaction_between_CBD_and_metoprolol_could_lead_to_positive_effects_or_conversely_generate_unwanted_risks\" >As mentioned previously, some preclinical research has demonstrated a cardiovascular protective effect of CBD. While this may seem beneficial at first, it is difficult to assess, without reliable clinical data, whether this interaction between CBD and metoprolol could lead to positive effects or, conversely, generate unwanted risks.<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.cbd.fr\/blog\/en\/interactions-between-cbd-and-metoprolol-what-you-need-to-know\/#Precautions_and_advice\" >Precautions and advice<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.cbd.fr\/blog\/en\/interactions-between-cbd-and-metoprolol-what-you-need-to-know\/#In_summary\" >In summary<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Numerous_studies_have_highlighted_the_therapeutic_properties_of_CBD_such_as_its_anti-inflammatory_and_antioxidant_effects_its_ability_to_reduce_stress_anxiety_and_even_some_forms_of_epilepsy_It_has_also_demonstrated_cardiovascular_protective_effects_in_some_preclinical_studies\"><\/span>Numerous studies have highlighted the therapeutic properties of CBD, such as its anti-inflammatory and antioxidant effects, its ability to reduce stress, anxiety, and even some forms of epilepsy. It has also demonstrated cardiovascular protective effects in some preclinical studies.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Metoprolol: Overview and Indications<\/p>\n<p>Metoprolol is a medication belonging to the class of selective beta-blockers. It is marketed under various brand names such as<\/p>\n<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Lopressor_Toprol-XL_Beloc-Zok_and_Metohexal\"><\/span>Lopressor, Toprol-XL, Beloc-Zok, and Metohexal.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p> <strong>This medication is primarily prescribed to treat cardiovascular problems, including:<\/strong>high blood pressure (hypertension)<\/p>\n<ul>\n<li>angina pectoralis major (or pectoral angina)<\/li>\n<li>arrhythmias<\/li>\n<li>prevention of heart attacks<\/li>\n<li>Metoprolol works by blocking the stimulation of beta-adrenergic receptors\u2014present in the heart and other parts of the body\u2014by catecholamines (such as adrenaline). This slows the heart rate and reduces the force with which the heart contracts, thus lowering blood pressure.<\/li>\n<\/ul>\n<p>Potential Interactions Between CBD and Metoprolol<\/p>\n<\/p>\n<h2><span class=\"ez-toc-section\" id=\"It_is_important_to_note_that_there_is_currently_no_robust_clinical_data_regarding_potential_specific_interactions_between_CBD_and_metoprolol\"><\/span>It is important to note that there is currently no robust clinical data regarding potential specific interactions between CBD and metoprolol.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Inhibition of Metoprolol Metabolism<\/p>\n<h3><span class=\"ez-toc-section\" id=\"However_some_studies_have_highlighted_CBDs_potential_to_inhibit_a_liver_enzyme_called_cytochrome_P450_CYP450_which_is_responsible_for_metabolizing_approximately_60_of_medications_available_on_the_market_including_metoprolol\"><\/span>However, some studies have highlighted CBD&#8217;s potential to inhibit a liver enzyme called cytochrome P450 (CYP450), which is responsible for metabolizing approximately 60% of medications available on the market, including metoprolol.<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>By inhibiting this enzyme, CBD could thus increase metoprolol levels in the body and potentially cause side effects such as:<\/p>\n<p>dizziness<\/p>\n<ul>\n<li>fatigue<\/li>\n<li>a significant drop in blood pressure (hypotension)<\/li>\n<li>an excessively slow heart rate (bradycardia)<\/li>\n<li>These adverse effects could be particularly concerning for individuals already prone to these symptoms or with underlying health conditions.<\/li>\n<\/ul>\n<p>Synergistic Effects on Cardiovascular Properties<\/p>\n<\/p>\n<h3><span class=\"ez-toc-section\" id=\"As_mentioned_previously_some_preclinical_research_has_demonstrated_a_cardiovascular_protective_effect_of_CBD_While_this_may_seem_beneficial_at_first_it_is_difficult_to_assess_without_reliable_clinical_data_whether_this_interaction_between_CBD_and_metoprolol_could_lead_to_positive_effects_or_conversely_generate_unwanted_risks\"><\/span>As mentioned previously, some preclinical research has demonstrated a cardiovascular protective effect of CBD. While this may seem beneficial at first, it is difficult to assess, without reliable clinical data, whether this interaction between CBD and metoprolol could lead to positive effects or, conversely, generate unwanted risks.<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Precautions_and_advice\"><\/span>Precautions and advice<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>If you are considering taking CBD in conjunction with metoprolol, we recommend that you:<\/p>\n<ul>\n<li>speak to your doctor or pharmacist beforehand so they can inform you about the potential risks and adjust your treatments or dosages if necessary;<\/li>\n<li>carefully monitor for any side effects and report them promptly to your healthcare professional;<\/li>\n<li>ensure the quality of the CBD product by choosing a reliable supplier who is transparent about the certifications, tests, and dosages performed on their products.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"In_summary\"><\/span>In summary<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>It is still difficult to accurately assess the interactions between CBD and metoprolol due to a lack of clinical data. However, some studies suggest that CBD may inhibit the metabolism of metoprolol, potentially leading to adverse effects. If you wish to combine these two substances, it is advisable to consult your doctor to discuss the potential risks and adjust your treatment if necessary.<\/p>\n\n\n<div class=\"kk-star-ratings kksr-auto kksr-align-left kksr-valign-bottom\"\n    data-payload='{&quot;align&quot;:&quot;left&quot;,&quot;id&quot;:&quot;17372&quot;,&quot;slug&quot;:&quot;default&quot;,&quot;valign&quot;:&quot;bottom&quot;,&quot;ignore&quot;:&quot;&quot;,&quot;reference&quot;:&quot;auto&quot;,&quot;class&quot;:&quot;&quot;,&quot;count&quot;:&quot;0&quot;,&quot;legendonly&quot;:&quot;&quot;,&quot;readonly&quot;:&quot;&quot;,&quot;score&quot;:&quot;0&quot;,&quot;starsonly&quot;:&quot;&quot;,&quot;best&quot;:&quot;5&quot;,&quot;gap&quot;:&quot;5&quot;,&quot;greet&quot;:&quot;Notez cet article&quot;,&quot;legend&quot;:&quot;0\\\/5 - (0 vote)&quot;,&quot;size&quot;:&quot;24&quot;,&quot;title&quot;:&quot;Interactions between CBD and Metoprolol: what you need to know&quot;,&quot;width&quot;:&quot;0&quot;,&quot;_legend&quot;:&quot;{score}\\\/{best} - ({count} {votes})&quot;,&quot;font_factor&quot;:&quot;1.25&quot;}'>\n            \n<div class=\"kksr-stars\">\n    \n<div class=\"kksr-stars-inactive\">\n            <div class=\"kksr-star\" data-star=\"1\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"2\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"3\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"4\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"5\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n    <\/div>\n    \n<div class=\"kksr-stars-active\" style=\"width: 0px;\">\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n    <\/div>\n<\/div>\n                \n\n<div class=\"kksr-legend\" style=\"font-size: 19.2px;\">\n            <span class=\"kksr-muted\">Notez cet article<\/span>\n    <\/div>\n    <\/div>\n","protected":false},"excerpt":{"rendered":"<p>CBD (cannabidiol) is increasingly popular for its numerous health benefits. However, it is essential to be well-informed about potential interactions with other medications, particularly metoprolol. In this article, we will discuss the different characteristics of CBD and metoprolol, as well as their possible interactions. What is CBD? Cannabidiol (CBD) is a compound extracted from the [&hellip;]<\/p>\n","protected":false},"author":90,"featured_media":12114,"comment_status":"closed","ping_status":"open","sticky":false,"template":"default\n","format":"standard","meta":{"_sitemap_exclude":false,"_sitemap_priority":"","_sitemap_frequency":"","footnotes":""},"categories":[999],"tags":[],"class_list":["post-17372","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sante-et-cbd-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.9 (Yoast SEO v26.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Interactions between CBD and Metoprolol: what you need to know - CBD Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cbd.fr\/blog\/en\/interactions-between-cbd-and-metoprolol-what-you-need-to-know\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\ud83c\udf31Interactions between CBD and Metoprolol: what you need to know - CBD.fr \ud83c\udf31\" \/>\n<meta property=\"og:description\" content=\"CBD (cannabidiol) is increasingly popular for its numerous health benefits. However, it is essential to be well-informed about potential interactions with other medications, particularly metoprolol. In this article, we will discuss the different characteristics of CBD and metoprolol, as well as their possible interactions. What is CBD? Cannabidiol (CBD) is a compound extracted from the [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cbd.fr\/blog\/en\/interactions-between-cbd-and-metoprolol-what-you-need-to-know\/\" \/>\n<meta property=\"og:site_name\" content=\"CBD Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/cbdfrr\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-13T16:27:36+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-13T16:27:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cbd.fr\/blog\/wp-content\/uploads\/2024\/03\/interactions-entre-le-cbd-et-le-metoprolol-ce-que-vous-devez-savoir.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1456\" \/>\n\t<meta property=\"og:image:height\" content=\"832\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Julien\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Julien\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Interactions between CBD and Metoprolol: what you need to know - CBD Blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cbd.fr\/blog\/en\/interactions-between-cbd-and-metoprolol-what-you-need-to-know\/","og_locale":"fr_FR","og_type":"article","og_title":"\ud83c\udf31Interactions between CBD and Metoprolol: what you need to know - CBD.fr \ud83c\udf31","og_description":"CBD (cannabidiol) is increasingly popular for its numerous health benefits. However, it is essential to be well-informed about potential interactions with other medications, particularly metoprolol. In this article, we will discuss the different characteristics of CBD and metoprolol, as well as their possible interactions. What is CBD? 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