{"id":18777,"date":"2026-02-13T18:09:37","date_gmt":"2026-02-13T17:09:37","guid":{"rendered":"https:\/\/www.cbd.fr\/blog\/?p=18777"},"modified":"2026-02-13T18:09:38","modified_gmt":"2026-02-13T17:09:38","slug":"drug-interactions-which-treatments-should-be-avoided-with-cbd","status":"publish","type":"post","link":"https:\/\/www.cbd.fr\/blog\/en\/drug-interactions-which-treatments-should-be-avoided-with-cbd\/","title":{"rendered":"Drug interactions: Which treatments should be avoided with CBD?"},"content":{"rendered":"<\/p>\n<p>Cannabidiol (CBD) is a non-psychoactive component found in the cannabis plant. Its use is gaining popularity due to the numerous benefits it offers for various aspects of health. However, it is necessary to take certain precautions when using CBD, depending on other medications or treatments you are currently taking. In this article, we will discuss the main drug interactions with CBD and which medications should not be taken concurrently.<\/p>\n<h2><\/h2>\n<p>Main Drug Interactions with CBD<\/p>\n<p><strong><\/p>\n<p>Some studies have shown that CBD can interact with certain medications, which can lead to undesirable side effects. These interactions may be related to how CBD affects the immune system, the stomach, and other internal organs, as well as how it affects blood circulation. In all cases, it is essential to consult a specialist before introducing CBD into your treatment regimen if you are already taking another medication to avoid any negative interactions. Antidepressants:<\/p>\n<p><\/strong><\/p>\n<ol>\n<li><strong>Research shows that CBD can also increase serotonin levels, which may enhance the effect of antidepressants.<\/strong> Antihypertensives:<\/li>\n<li><strong>CBD has a hypotensive effect, meaning it can lower blood pressure. If you are taking antihypertensive medications\u2014such as diuretics or angiotensin-converting enzyme (ACE) inhibitors\u2014CBD could potentially enhance their effects.<\/strong> Sedatives:<\/li>\n<li><strong>CBD has also been found to have a sedative effect in some people, especially at high doses. If you are taking sedative medications such as benzodiazepines, it is important to carefully monitor your dosage and be aware of potential interactions with CBD.<\/strong> Medications to Avoid When Using CBD<\/li>\n<\/ol>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_80 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Sommaire<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #43b981;color:#43b981\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #43b981;color:#43b981\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.cbd.fr\/blog\/en\/drug-interactions-which-treatments-should-be-avoided-with-cbd\/#According_to_available_research_here_are_some_of_the_types_of_medications_that_may_interact_with_CBD\" >According to available research, here are some of the types of medications that may interact with CBD:<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.cbd.fr\/blog\/en\/drug-interactions-which-treatments-should-be-avoided-with-cbd\/#Medications_Incompatible_with_the_Endocannabinoid_System\" >Medications Incompatible with the Endocannabinoid System<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"According_to_available_research_here_are_some_of_the_types_of_medications_that_may_interact_with_CBD\"><\/span>According to available research, here are some of the types of medications that may interact with CBD:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Liver-metabolized medications:<\/p>\n<ul>\n<li><strong>Some studies suggest that CBD may inhibit certain liver enzymes responsible for breaking down medications (CYP450). This means that if you are taking medications that are also metabolized by these enzymes, using CBD concurrently could disrupt this breakdown, thus increasing the concentration of the medication in your body.<\/strong> Blood thinners:<\/li>\n<li><strong>CBD&#8217;s blood-thinning effects may enhance those of blood-thinning medications such as warfarin, increasing the risk of bleeding.<\/strong> Seizure medications:<\/li>\n<li><strong>CBD is used to treat epilepsy in the form of Epidiolex\u00ae, an FDA-approved medication. However, CBD has been shown to interact with certain seizure medications such as clobazam and may increase blood levels of this drug. Patients should therefore consult their doctor before combining CBD with these treatments.<\/strong> <\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Medications_Incompatible_with_the_Endocannabinoid_System\"><\/span>Medications Incompatible with the Endocannabinoid System<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>The endocannabinoid system (ECS) is a network of receptors in our bodies that plays a central role in regulating essential bodily functions. CBD works in part by influencing the ECS, but some medications can also interfere with it:<\/p>\n<ul>\n<li><strong>Rimonabant:<\/strong> This medication was developed to treat obesity and smoking, but its use was discontinued due to side effects such as anxiety and depression. It works by blocking CB1 receptors in the ECS, which means it could potentially interact with CBD as well.<\/li>\n<li><strong>Oleoylethanolamine (OEA):<\/strong> This is a natural compound produced by our body that acts on the ECS (endocannabinoid system). Medications are currently being developed to manipulate OEA (oxygenase-dependent enzyme) levels, with the aim of treating disorders such as anorexia and depression. In this case as well, there could be an interaction with CBD.<\/li>\n<\/ul>\n<h2><\/h2>\n<p>Medical consultation and necessary precautions <strong>As stated previously, when using CBD alongside other medications,<\/strong>it is always best to consult a healthcare professional to learn about possible interactions between the substances and adjust your dosage accordingly.<\/p>\n\n\n<div class=\"kk-star-ratings kksr-auto kksr-align-left kksr-valign-bottom\"\n    data-payload='{&quot;align&quot;:&quot;left&quot;,&quot;id&quot;:&quot;18777&quot;,&quot;slug&quot;:&quot;default&quot;,&quot;valign&quot;:&quot;bottom&quot;,&quot;ignore&quot;:&quot;&quot;,&quot;reference&quot;:&quot;auto&quot;,&quot;class&quot;:&quot;&quot;,&quot;count&quot;:&quot;0&quot;,&quot;legendonly&quot;:&quot;&quot;,&quot;readonly&quot;:&quot;&quot;,&quot;score&quot;:&quot;0&quot;,&quot;starsonly&quot;:&quot;&quot;,&quot;best&quot;:&quot;5&quot;,&quot;gap&quot;:&quot;5&quot;,&quot;greet&quot;:&quot;Notez cet article&quot;,&quot;legend&quot;:&quot;0\\\/5 - (0 vote)&quot;,&quot;size&quot;:&quot;24&quot;,&quot;title&quot;:&quot;Drug interactions: Which treatments should be avoided with CBD?&quot;,&quot;width&quot;:&quot;0&quot;,&quot;_legend&quot;:&quot;{score}\\\/{best} - ({count} {votes})&quot;,&quot;font_factor&quot;:&quot;1.25&quot;}'>\n            \n<div class=\"kksr-stars\">\n    \n<div class=\"kksr-stars-inactive\">\n            <div class=\"kksr-star\" data-star=\"1\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"2\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"3\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"4\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"5\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n    <\/div>\n    \n<div class=\"kksr-stars-active\" style=\"width: 0px;\">\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n    <\/div>\n<\/div>\n                \n\n<div class=\"kksr-legend\" style=\"font-size: 19.2px;\">\n            <span class=\"kksr-muted\">Notez cet article<\/span>\n    <\/div>\n    <\/div>\n","protected":false},"excerpt":{"rendered":"<p>Cannabidiol (CBD) is a non-psychoactive component found in the cannabis plant. Its use is gaining popularity due to the numerous benefits it offers for various aspects of health. However, it is necessary to take certain precautions when using CBD, depending on other medications or treatments you are currently taking. In this article, we will discuss [&hellip;]<\/p>\n","protected":false},"author":90,"featured_media":11557,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_sitemap_exclude":false,"_sitemap_priority":"","_sitemap_frequency":"","footnotes":""},"categories":[923],"tags":[],"class_list":["post-18777","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faq-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.9 (Yoast SEO v26.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Drug interactions: Which treatments should be avoided with CBD? - CBD Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cbd.fr\/blog\/en\/drug-interactions-which-treatments-should-be-avoided-with-cbd\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\ud83c\udf31Drug interactions: Which treatments should be avoided with CBD? - CBD.fr \ud83c\udf31\" \/>\n<meta property=\"og:description\" content=\"Cannabidiol (CBD) is a non-psychoactive component found in the cannabis plant. 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Its use is gaining popularity due to the numerous benefits it offers for various aspects of health. However, it is necessary to take certain precautions when using CBD, depending on other medications or treatments you are currently taking. In this article, we will discuss [&hellip;]","og_url":"https:\/\/www.cbd.fr\/blog\/en\/drug-interactions-which-treatments-should-be-avoided-with-cbd\/","og_site_name":"CBD Blog","article_publisher":"https:\/\/www.facebook.com\/cbdfrr\/","article_published_time":"2026-02-13T17:09:37+00:00","article_modified_time":"2026-02-13T17:09:38+00:00","og_image":[{"width":1456,"height":832,"url":"https:\/\/www.cbd.fr\/blog\/wp-content\/uploads\/2024\/01\/interactions-medicamenteuses-quels-traitements-a-eviter-avec-le-cbd.jpg","type":"image\/jpeg"}],"author":"Julien","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"Julien","Dur\u00e9e de lecture estim\u00e9e":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.cbd.fr\/blog\/en\/drug-interactions-which-treatments-should-be-avoided-with-cbd\/#article","isPartOf":{"@id":"https:\/\/www.cbd.fr\/blog\/en\/drug-interactions-which-treatments-should-be-avoided-with-cbd\/"},"author":{"name":"Julien","@id":"https:\/\/www.cbd.fr\/blog\/#\/schema\/person\/d78b472d184ec8ae4135d454e3338c04"},"headline":"Drug interactions: Which treatments should be avoided with CBD?","datePublished":"2026-02-13T17:09:37+00:00","dateModified":"2026-02-13T17:09:38+00:00","mainEntityOfPage":{"@id":"https:\/\/www.cbd.fr\/blog\/en\/drug-interactions-which-treatments-should-be-avoided-with-cbd\/"},"wordCount":565,"publisher":{"@id":"https:\/\/www.cbd.fr\/blog\/#organization"},"image":{"@id":"https:\/\/www.cbd.fr\/blog\/en\/drug-interactions-which-treatments-should-be-avoided-with-cbd\/#primaryimage"},"thumbnailUrl":"https:\/\/www.cbd.fr\/blog\/wp-content\/uploads\/2024\/01\/interactions-medicamenteuses-quels-traitements-a-eviter-avec-le-cbd.jpg","articleSection":["Frequently asked questions"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/www.cbd.fr\/blog\/en\/drug-interactions-which-treatments-should-be-avoided-with-cbd\/","url":"https:\/\/www.cbd.fr\/blog\/en\/drug-interactions-which-treatments-should-be-avoided-with-cbd\/","name":"Drug interactions: Which treatments should be avoided with CBD? 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Expertise, qualit\u00e9 et p\u00e9dagogie sont au c\u0153ur de l\u2019exp\u00e9rience CBD.fr.","email":"support@cbd.fr","telephone":"0189720196","legalName":"CBD.fr","foundingDate":"2021-01-01","taxID":"760933","numberOfEmployees":{"@type":"QuantitativeValue","minValue":"11","maxValue":"50"}},{"@type":"Person","@id":"https:\/\/www.cbd.fr\/blog\/#\/schema\/person\/d78b472d184ec8ae4135d454e3338c04","name":"Julien","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.cbd.fr\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/58f2f1b1e71c329d0226efe2cc40174640e1757e077dac013c980f3ee43c73a0?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/58f2f1b1e71c329d0226efe2cc40174640e1757e077dac013c980f3ee43c73a0?s=96&d=mm&r=g","caption":"Julien"},"description":"R\u00e9dacteur en chef sp\u00e9cialis\u00e9 en CBD Julien, n\u00e9 le 17 juillet 1978 en r\u00e9gion Parisienne, est un \u00e9minent r\u00e9dacteur et expert dans le domaine des produits \u00e0 base de CBD. Suite \u00e0 ses \u00e9tudes, Julien a d\u00e9velopp\u00e9 une passion pour les rem\u00e8des naturels, dont le CBD. En 2022, il int\u00e8gre l\u2019\u00e9quipe du site CBD.fr en qualit\u00e9 d\u2019expert et de contributeur r\u00e9gulier. Gr\u00e2ce \u00e0 son expertise scientifique et une \u00e9criture claire, Julien aide \u00e0 d\u00e9mystifier les aspects complexes du CBD, tout en mettant en lumi\u00e8re ses bienfaits et applications potentielles \u00e0 travers ses articles et participations \u00e0 des conf\u00e9rences.","honorificPrefix":"Mr","gender":"male","knowsAbout":["CBD","Cannabis","Copywriter"],"knowsLanguage":["French"],"jobTitle":"Editor-in-chief specializing in CBD","worksFor":"CBD.fr","url":"https:\/\/www.cbd.fr\/blog\/author\/redac-cbd\/"}]}},"_links":{"self":[{"href":"https:\/\/www.cbd.fr\/blog\/wp-json\/wp\/v2\/posts\/18777","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cbd.fr\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cbd.fr\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cbd.fr\/blog\/wp-json\/wp\/v2\/users\/90"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cbd.fr\/blog\/wp-json\/wp\/v2\/comments?post=18777"}],"version-history":[{"count":1,"href":"https:\/\/www.cbd.fr\/blog\/wp-json\/wp\/v2\/posts\/18777\/revisions"}],"predecessor-version":[{"id":18778,"href":"https:\/\/www.cbd.fr\/blog\/wp-json\/wp\/v2\/posts\/18777\/revisions\/18778"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.cbd.fr\/blog\/wp-json\/wp\/v2\/media\/11557"}],"wp:attachment":[{"href":"https:\/\/www.cbd.fr\/blog\/wp-json\/wp\/v2\/media?parent=18777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cbd.fr\/blog\/wp-json\/wp\/v2\/categories?post=18777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cbd.fr\/blog\/wp-json\/wp\/v2\/tags?post=18777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}