Cannabidiol (CBD) is a non-psychoactive component found in the cannabis plant. Its use is gaining popularity due to the numerous benefits it offers for various aspects of health. However, it is necessary to take certain precautions when using CBD, depending on other medications or treatments you are currently taking. In this article, we will discuss the main drug interactions with CBD and which medications should not be taken concurrently.
Main Drug Interactions with CBD
Some studies have shown that CBD can interact with certain medications, which can lead to undesirable side effects. These interactions may be related to how CBD affects the immune system, the stomach, and other internal organs, as well as how it affects blood circulation. In all cases, it is essential to consult a specialist before introducing CBD into your treatment regimen if you are already taking another medication to avoid any negative interactions. Antidepressants:
- Research shows that CBD can also increase serotonin levels, which may enhance the effect of antidepressants. Antihypertensives:
- CBD has a hypotensive effect, meaning it can lower blood pressure. If you are taking antihypertensive medications—such as diuretics or angiotensin-converting enzyme (ACE) inhibitors—CBD could potentially enhance their effects. Sedatives:
- CBD has also been found to have a sedative effect in some people, especially at high doses. If you are taking sedative medications such as benzodiazepines, it is important to carefully monitor your dosage and be aware of potential interactions with CBD. Medications to Avoid When Using CBD
According to available research, here are some of the types of medications that may interact with CBD:
Liver-metabolized medications:
- Some studies suggest that CBD may inhibit certain liver enzymes responsible for breaking down medications (CYP450). This means that if you are taking medications that are also metabolized by these enzymes, using CBD concurrently could disrupt this breakdown, thus increasing the concentration of the medication in your body. Blood thinners:
- CBD’s blood-thinning effects may enhance those of blood-thinning medications such as warfarin, increasing the risk of bleeding. Seizure medications:
- CBD is used to treat epilepsy in the form of Epidiolex®, an FDA-approved medication. However, CBD has been shown to interact with certain seizure medications such as clobazam and may increase blood levels of this drug. Patients should therefore consult their doctor before combining CBD with these treatments.
Medications Incompatible with the Endocannabinoid System
The endocannabinoid system (ECS) is a network of receptors in our bodies that plays a central role in regulating essential bodily functions. CBD works in part by influencing the ECS, but some medications can also interfere with it:
- Rimonabant: This medication was developed to treat obesity and smoking, but its use was discontinued due to side effects such as anxiety and depression. It works by blocking CB1 receptors in the ECS, which means it could potentially interact with CBD as well.
- Oleoylethanolamine (OEA): This is a natural compound produced by our body that acts on the ECS (endocannabinoid system). Medications are currently being developed to manipulate OEA (oxygenase-dependent enzyme) levels, with the aim of treating disorders such as anorexia and depression. In this case as well, there could be an interaction with CBD.
Medical consultation and necessary precautions As stated previously, when using CBD alongside other medications,it is always best to consult a healthcare professional to learn about possible interactions between the substances and adjust your dosage accordingly.
