Cannabidiol (CBD) is a non-psychoactive substance found in the cannabis plant. It is widely used for its therapeutic effects, such as reducing anxiety, inflammation, pain, and other medical conditions. As research on CBD increases, it is essential to understand how it may interact with commonly prescribed medications, such as blood thinners (anticoagulants). In this article, we will examine the potential interactions between CBD and blood thinners, including two of the most popular: warfarin and Eliquis.
Blood Thinners and How They Work Blood thinners are medications used to prevent blood clots from forming when a person has thrombosis or a stroke. They work by slowing blood clotting to allow blood to flow freely through the vessels. Two of the main blood thinners on the market are warfarin and Eliquis. Warfarin Warfarin is a commonly prescribed oral anticoagulant that has been used for decades to prevent strokes and blood clots in high-risk patients. People with certain heart conditions, such as atrial fibrillation (an irregular heartbeat), artificial heart valves, or those who have recently undergone surgery, are often prescribed warfarin. Eliquis
Eliquis is another oral anticoagulant that inhibits blood clotting by blocking the action of a specific factor in the blood clotting process. It is prescribed to prevent strokes and other complications in patients with conditions such as atrial fibrillation, pulmonary embolisms, and/or deep vein thrombosis.
CBD and its metabolism
In our bodies, CBD—like various other medications—is primarily metabolized by the enzyme system called cytochrome P450 when taken orally. Many of these enzymes also play a major role in the metabolism of medications, including certain blood thinners such as warfarin and Eliquis.
Potential Interactions Between CBD and Blood Thinners
While studies on the potential interactions between CBD and blood thinners are still limited, some research suggests that cannabidiol may influence the levels of these medications in the body, potentially leading to complications. CBD and Warfarin A study published in the journal *Epilepsy & Behavior Case Reports* found that a child with Dravet syndrome—a rare form of childhood epilepsy—developed abnormal bleeding during combined treatment with CBD oil (Epidiolex) and warfarin. The study suggests that
CBD increased the plasma concentration of warfarin,
highlighting the importance of careful monitoring of anticoagulant efficacy and therapeutic balance when using CBD and warfarin concomitantly.
CBD and Eliquis There is currently no specific research on the interactions between CBD and Eliquis. However, since cytochrome P450 also plays a role in the metabolism of Eliquis, it is plausible that the same type of interaction is possible. Therefore, caution should be exercised whenconsuming CBD concurrently with Eliquis.
Precautions to consider
Consult a healthcare professional: Before starting or changing your CBD dosage, it is essential to consult a doctor or pharmacist who will take into account your current medications and overall health. Close monitoring
For patients already taking anticoagulants, close monitoring of anticoagulant efficacy, plasma drug levels, and signs of bleeding or clotting is crucial when using CBD.
- Inform your doctor of any changes: If you experience any side effects while using CBD and anticoagulants, talk to your doctor as soon as possible to adjust dosages or consider alternative treatment options.
- In conclusion, although research on the interactions between CBD and anticoagulants is still limited, the available data suggest a significant potential for interaction that requires careful attention. Consulting a healthcare professional and careful monitoring of symptoms are essential to ensure the safety and effectiveness of concomitant treatment with CBD and anticoagulant medications such as warfarin and Eliquis.
