CBD, or cannabidiol, is a molecule found in the cannabis plant that is generating increasing interest due to its potential health benefits. More and more commonly used in the form of oil, capsules, or creams, it can interact with certain medications, including esomeprazole, a proton pump inhibitor prescribed to treat gastrointestinal problems such as gastroesophageal reflux disease (GERD).
What is CBD and why is it popular? CBD’s popularity stems from its purported therapeutic effects, particularly in relieving anxiety, reducing chronic and inflammatory pain, and improving sleep quality. Unlike THC, another major component of cannabis, CBD has no psychoactive effects and therefore does not produce a “high.” This characteristic allows it to be legal in many countries and explains its appeal to an ever-growing audience.
Esomeprazole and its common use Esomeprazole belongs to the proton pump inhibitor (PPI) family and is generally prescribed to treat disorders associated with gastric acidity, such as gastroesophageal reflux disease (GERD), gastric ulcers, or Helicobacter pylori infection. Its main role is toreduce acid production in the stomach
, thus relieving the symptoms associated with these disorders and facilitating the healing of any lesions.
The interaction between CBD and esomeprazole It should be noted that taking CBD and esomeprazole simultaneously can lead to certain drug interactions. These interactions may be caused by the fact thatboth substances are metabolized by the same set of enzymes, called cytochrome P450 (CYP)
CYP enzymes and their role in the body
CYP enzymes are primarily found in the liver and break down foreign molecules that enter our bodies, such as medications and dietary supplements. Therefore, they play a key role in how we absorb, use, and eliminate these substances.
In this context, CYP enzymes are also involved in the metabolism of CBD, transforming it into a more water-soluble form that allows for its elimination by the body. Similarly, CYP enzymes are responsible for converting esomeprazole into its active form, which then exerts its inhibitory effect on the proton pump. CBD Enzyme Inhibition and ConsequencesThe problem arises when CBD, by interacting with CYP enzymes, inhibits their function. In other words,
- the presence of CBD can lead to a decrease in the activity of CYP enzymes,
which can have several consequences:
Slowing of the metabolism of esomeprazole, which can lead to an increase in its concentration in the blood and potentially cause more pronounced or prolonged side effects.
Decreased effectiveness of esomeprazole if the conversion to its active form is too low.
- Conversely, the metabolism of CBD can also be disrupted, thus altering its expected effects.
- It is important to emphasize that these interactions can vary from person to person, depending on factors such as dosage, frequency of use, or individual genetics influencing drug metabolism. Caution and recommendations for combining CBD and esomeprazoleDue to this potential interaction between CBD and esomeprazole, it is recommended to be vigilant when combining the two substances. Here are some tips to minimize the risks when taken together:
- Consult a healthcare professional
before starting CBD treatment if you are already taking esomeprazole or other medications metabolized by CYP enzymes. They can adjust your dosage and closely monitor the effects of this combination.
