In this article, we will discuss a topic of growing interest: the interaction between cannabidiol (CBD), a substance extracted from cannabis, and metformin, a medication commonly used to treat type 2 diabetes. Both substances are increasingly popular worldwide, making it essential to understand how they may interact and what the potential consequences of this interaction might be.
What is CBD? CBD is a non-psychoactive compound found in cannabis.
Unlike THC, the other main constituent of cannabis, it does not produce the psychotropic effects often associated with the plant. CBD has been studied for its potential therapeutic properties, particularly in the areas of pain management, neuroprotection, anxiety reduction, and epilepsy.
- The Various Forms of CBD
- Today, a wide range of CBD products are available, including:
- Oils
- Capsules
Ointments and Balms
Tints E-liquids for Electronic CigarettesMetformin, a Diabetes Medication
Metformin is a well-known medication used to treat type 2 diabetes. By increasing the sensitivity of cells to insulin,
metformin allows blood sugar to be better absorbed by tissues,
- which reduces blood glucose levels and limits the complications caused by chronic hyperglycemia.
- Mechanism of Action of Metformin
- Among its proven mechanisms of action, metformin is known to:
Decrease glucose production by the liver
Increase the muscles’ ability to absorb glucose
Slightly impair glucose absorption by the intestine
This medication is generally prescribed in tablet form.
Research and Studies: What about the interaction between CBD and metformin?The interactions between CBD and metformin are still poorly understood, so the scientific evidence is currently limited. However, some preliminary data suggest that certain interactions may occur, particularly in terms of CBD bioavailability and the metabolism of the two substances. It should be noted, however, that these results are not necessarily representative of how these interactions may manifest in all individuals.
The influence of CBD on metformin bioavailability Recent studies have suggested that CBD may interact with certain cellular transporters involved in metformin absorption.
By binding to these transporters, CBD could potentially reduce the availability of metformin to cells and thus decrease its effectiveness. However, it is important to emphasize that these results are preliminary and need to be confirmed by further research.
Effect of CBD and metformin on the liver: possible interaction at the metabolic level
Both CBD and metformin are metabolized by the liver, primarily via the cytochrome P450 enzyme system. This means they could potentially compete for degradation by these enzymes,
which could result in a change—either an increase or a decrease—in their concentration in the body and therefore in their therapeutic effects. However, this hypothesis needs to be verified by further studies.
