In many countries, research on the effects of cannabis, and more specifically CBD (cannabidiol), is increasing, highlighting potential interactions between this substance and other commonly prescribed medications. Among these, metamizole, also known as Novalgin, Novaminsulfon, or Nolotil, is receiving particular attention. This article aims to examine the various possible interactions between CBD and metamizole, as well as the potential risks that could result. What is metamizole and why is it used? Metamizole is a non-opioid analgesic, meaning its primary purpose is to reduce pain without causing dependence on opiate substances such as morphine. Initially marketed in 1922, it remains one of the most popular analgesics in several European countries and in Latin America. Metamizole, commonly prescribed in tablet or oral solution form, is used to treat various medical conditions, including:headaches dental pain post-surgical pain muscle or joint painsevere infections accompanied by fever
What is CBD and why is it used?
CBD (cannabidiol) is a component of cannabis, a plant also known as hemp. Unlike THC (tetrahydrocannabinol), the other major compound in cannabis, which has psychoactive effects, CBD does not affect perception or consciousness. Instead, it has interesting pharmacological properties for both modern and alternative medicine. Today, numerous studies have demonstrated the potential effectiveness of CBD in treating various medical conditions, including:
chronic pain
- epilepsy
- anxiety disorders
- depression
- inflammation
- cancer
The Interaction Between CBD and Metamizole: What We Know Today
Research on the interactions between CBD and metamizole is still in its early stages, but several studies already suggest that these two substances could have a synergistic effect, meaning they could potentiate each other’s effects when used together. Analgesic Effects
The first area of potential interaction between CBD and metamizole concerns their analgesic properties. Indeed, preclinical studies on animal models of pain have shown that the combined administration of CBD and metamizole resulted in a greater reduction in the sensation of pain than the use of each substance separately.
- These results suggest that a combination of CBD and metamizole could be considered for the treatment of certain painful conditions, with a potential benefit for patients who do not respond adequately to conventional treatments or who wish to avoid the side effects associated with opioids.
- Anti-inflammatory effects
- Although the mechanisms of action of CBD and metamizole differ, it is worth noting that both substances possess anti-inflammatory properties. In vitro studies have demonstrated that combining these two molecules could produce an enhanced anti-inflammatory effect, potentially beneficial for the treatment of chronic inflammatory diseases.
Potential risks associated with the combined use of CBD and metamizole
However, caution is advised regarding the combined use of CBD and metamizole due to potential adverse effects or pharmacokinetic interactions. In particular, a major concern is the possible interaction between CBD and cytochrome P450 (CYP), a group of enzymes found in the liver and involved in drug metabolism.
Some studies have suggested that CBD may inhibit the activity of certain CYP enzymes, including CYP2C9, which is also responsible for metamizole degradation. Consequently, the concurrent administration of CBD and metamizole could lead to an increase in plasma concentrations of the latter, with a heightened risk of side effects or toxicity.
Consultations
Given these uncertainties, it is best to discuss this with your doctor before starting combined treatment with CBD and metamizole. It will then be essential to closely monitor plasma concentrations of metamizole and its active metabolites, as well as to regularly monitor liver and kidney function. Furthermore, it may be helpful to avoid using high doses of CBD to limit the risk of pharmacokinetic interactions.
Finally, it is also important to remember that CBD use is not without risk and can cause side effects such as drowsiness, dizziness, and interactions with other medications like anticoagulants or antiepileptics. As always, it is crucial to be well-informed and choose high-quality products made with pure CBD extracted from organically grown cannabis plants.
