CBD (cannabidiol) is increasingly popular for its numerous health benefits. However, it is essential to be well-informed about potential interactions with other medications, particularly metoprolol. In this article, we will discuss the different characteristics of CBD and metoprolol, as well as their possible interactions. What is CBD? Cannabidiol (CBD) is a compound extracted from the cannabis plant. Unlike THC, the other major component of cannabis, CBD does not produce psychoactive effects and therefore does not induce a “high.” It acts primarily on the body’s endocannabinoid system, regulating various physiological processes such as pain, anxiety, and sleep.
Numerous studies have highlighted the therapeutic properties of CBD, such as its anti-inflammatory and antioxidant effects, its ability to reduce stress, anxiety, and even some forms of epilepsy. It has also demonstrated cardiovascular protective effects in some preclinical studies.
Metoprolol: Overview and Indications
Metoprolol is a medication belonging to the class of selective beta-blockers. It is marketed under various brand names such as
Lopressor, Toprol-XL, Beloc-Zok, and Metohexal.
This medication is primarily prescribed to treat cardiovascular problems, including:high blood pressure (hypertension)
- angina pectoralis major (or pectoral angina)
- arrhythmias
- prevention of heart attacks
- Metoprolol works by blocking the stimulation of beta-adrenergic receptors—present in the heart and other parts of the body—by catecholamines (such as adrenaline). This slows the heart rate and reduces the force with which the heart contracts, thus lowering blood pressure.
Potential Interactions Between CBD and Metoprolol
It is important to note that there is currently no robust clinical data regarding potential specific interactions between CBD and metoprolol.
Inhibition of Metoprolol Metabolism
However, some studies have highlighted CBD’s potential to inhibit a liver enzyme called cytochrome P450 (CYP450), which is responsible for metabolizing approximately 60% of medications available on the market, including metoprolol.
By inhibiting this enzyme, CBD could thus increase metoprolol levels in the body and potentially cause side effects such as:
dizziness
- fatigue
- a significant drop in blood pressure (hypotension)
- an excessively slow heart rate (bradycardia)
- These adverse effects could be particularly concerning for individuals already prone to these symptoms or with underlying health conditions.
Synergistic Effects on Cardiovascular Properties
As mentioned previously, some preclinical research has demonstrated a cardiovascular protective effect of CBD. While this may seem beneficial at first, it is difficult to assess, without reliable clinical data, whether this interaction between CBD and metoprolol could lead to positive effects or, conversely, generate unwanted risks.
Precautions and advice
If you are considering taking CBD in conjunction with metoprolol, we recommend that you:
- speak to your doctor or pharmacist beforehand so they can inform you about the potential risks and adjust your treatments or dosages if necessary;
- carefully monitor for any side effects and report them promptly to your healthcare professional;
- ensure the quality of the CBD product by choosing a reliable supplier who is transparent about the certifications, tests, and dosages performed on their products.
In summary
It is still difficult to accurately assess the interactions between CBD and metoprolol due to a lack of clinical data. However, some studies suggest that CBD may inhibit the metabolism of metoprolol, potentially leading to adverse effects. If you wish to combine these two substances, it is advisable to consult your doctor to discuss the potential risks and adjust your treatment if necessary.
