The dangers of interactions between CBD and medications

Cannabidiol, more commonly known as CBD, is a molecule found in cannabis that is generating increasing interest for its therapeutic properties. Unlike THC, it does not produce psychoactive effects and can help alleviate various health problems, such as anxiety, pain, and even epilepsy. However, it is important to consider the potential risks of interactions between CBD and other medications. Why does CBD interact with certain medications?The main mechanism by which CBD can interact with other medications lies in its effect on the liver’s enzyme system. This system plays a crucial role in drug metabolism, as it breaks down ingested active substances, transforming them into inactive or less active compounds before they are eliminated from the body. CBD can inhibit or induce certain liver enzymes, thus altering how these other medications are metabolized in the body. Inhibition of cytochrome P450 enzymes

CBD has been identified as a potent inhibitor of cytochrome P450, a group of enzymes involved in the metabolism of many medications. If the activity level of these enzymes is reduced due to the presence of CBD, it means that other medications administered simultaneously are metabolized more slowly, and their effects in the body may then be prolonged and intensified.

Induction of other liver enzymes

In some cases, CBD can also induce certain liver enzymes, leading to an acceleration of the metabolism of the medications involved. The concentrations of these medications then decrease in the body, thus reducing their effectiveness and increasing the risk of undertreatment.

Which types of medications are affected by interactions with CBD?

While many substances can potentially interact with CBD, several categories of medications can be identified for which the risks of interaction are particularly significant:

Anticoagulants: CBD can increase blood levels of anticoagulants, such as warfarin, by inhibiting the enzymes responsible for their metabolism. This can lead to an increased risk of bleeding or serious adverse events associated with these medications.

Antiepileptics: Studies have shown that CBD can modulate the plasma concentrations of certain antiepileptic drugs, such as clobazam and valproate, amplifying their side effects and requiring dosage adjustments.

• Antidepressants and anxiolytics: Using CBD in combination with medications such as fluoxetine or diazepam can alter their effects and potentially exacerbate symptoms of anxiety or depression in some cases. Immunosuppressants : CBD can interact with certain immunosuppressants used to treat autoimmune diseases, modulating their therapeutic effect and increasing the risk of side effects.
• Other medications to watch out for
• In addition to these specific examples, there are also a number of medications that warrant special attention when used in combination with CBD. These include: nonsteroidal anti-inflammatory drugs (NSAIDs)
• medications used to lower blood pressure proton pump inhibitors (PPIs)

statins (cholesterol-lowering medications)

This list is not exhaustive, and it is always recommended to consult a healthcare professional before starting to use CBD, especially if you are already taking medication.

1. How to minimize the risk of drug interactions?
2. To reduce the risks associated with interactions between CBD and other medications, several precautions can be taken:
3. Consult a healthcare professional:
4. Before starting to use CBD, it is essential to discuss it with a doctor or pharmacist to assess the potential risks associated with your current treatment and determine an appropriate dosage. Be sure to list all the medications you are taking, including dietary supplements and herbal remedies.

Follow the dosage carefully:

Strictly adhere to the dosage recommended by your healthcare professional and never increase the CBD dose without their prior approval.

Monitor for the appearance of adverse symptoms:

• If you notice any unusual side effects after using CBD with other medications, stop using it immediately and contact your doctor. Keep in mind that some adverse reactions may only appear after several days or weeks of concurrent treatment. In summary, while CBD shows promising therapeutic potential for relieving numerous ailments, it is essential to consider possible drug interactions that could compromise the effectiveness of current treatments and/or cause adverse effects. Consulting a healthcare professional and remaining vigilant regarding any symptoms experienced remain the best ways to minimize these risks.

Julien( Rédacteur en chef spécialisé en CBD )