Thanks to evolving legislation and a growing interest in natural medicine, more and more cannabinoid-based products are being marketed. Most people are familiar with the best-known cannabinoid: CBD, a powerful and popular ingredient in many remedies. While you may know what THC is and that CBD is becoming increasingly popular, you might not be familiar with CBG and CBN. These fascinating minor cannabinoids (minor in name only) potentially hold the key to helping treat several different ailments. Here, we’ll take a closer look at the differences between these three substances and why they should pique your interest. You can learn more about CBD by clicking here: All About CBD (Cannabidiol) By far the most widely available cannabinoid on the market, cannabidiol (CBD) has become almost ubiquitous in recent years. Shops dedicated to this hemp derivative have sprung up all over the world, and online CBD sales have exploded. Comparing these three compounds, it turns out that CBD is abundant and easy to produce. This makes it the most economical cannabinoid after THC. It is generally derived from hemp plants (with a THC content of less than 0.3%). CBD is unanimously the best-known cannabinoid in cannabis.
This popularity of CBD is mainly due to its ease of extraction. Although it is often associated with THC, known for its psychoactive properties, it is important to clarify that CBD is a harmless cannabinoid.
Some properties and benefits of CBD
CBD has been the subject of several scientific studies. These studies have revealed its usefulness in treating certain conditions. Skin conditions
Applied to the skin as an oil or lotion, CBD is said to have an immediate effect. It possesses anti-inflammatory properties. Thus, people suffering from psoriasis, acne, or dermatitis would benefit from using it.Treatment of inflammation As mentioned previously, CBD has anti-inflammatory properties. Furthermore, it has proven very effective in treating pain. It is therefore indicated for calming joint or skin pain and inflammation.
Anxiety
In addition to its analgesic and anti-inflammatory properties, CBD is also said to have antidepressant properties. Specifically, CBD may stimulate the secretion of serotonin, the “happiness hormone.” Thus, this cannabinoid helps to calm anxiety and stress.
CBG (Cannabigerol): What is it?
CBG is short for Cannabigerol.
Like CBD and CBN, this compound is one of the many cannabinoids found in the cannabis plant. While it’s true that almost all cannabis plants contain this cannabinoid, it’s worth noting that it’s more abundant in younger plants. Despite its significant role in producing several cannabinoids, CBG has only recently become widely known. Yet, it’s the precursor to many cannabinoids, such as CBD and THC. This is why it’s often referred to as the “mother cannabinoid.”
Furthermore, CBG has a similar molecular weight and mass to CBD. This is why it is believed to share many of the same properties with CBD. Moreover, unlike CBD and THC, which are produced by the trichomes of the cannabis plant, CBG is obtained differently. In fact, it is derived from cannabigerolic acid (CBGA). CBGA, in turn, is converted through decarboxylation to yield other cannabinoids, such as THCA and CBDA.
The popularity of CBG-based products has increased significantly, with a global market value estimated at USD 8.33 billion in 2023 and a projected compound annual growth rate (CAGR) of 22% through 2033 (GlobeNewswire). Recent Studies on Cannabigerol
Here are some recent studies and their findings on the effects and therapeutic applications of CBG:
Synergistic Effects with Curcumin and Piperine
Another study explored the synergistic effects of CBG combined with curcumin and piperine on colon cancer cells. The results showed that this combination could have anti-tumorigenic effects by activating the Hippo YAP signaling pathway in certain cancer cell lines. This opens up possibilities for combination therapies using CBG in the treatment of colon cancer (Frontiers).
- Antibiotic PropertiesResearchers have discovered that CBG possesses potent antibiotic properties, particularly against MRSA (methicillin-resistant Staphylococcus aureus) infections. CBG has been shown to prevent the formation of bacterial biofilms and directly kill MRSA bacteria. This study indicates that CBG could be an effective alternative to traditional antibiotics, especially for drug-resistant infections (HealthMJ).
- Skin Health A study evaluated the effects of CBG on skin health, demonstrating that CBG could reduce levels of oxidative stress and pro-inflammatory cytokines in human skin models. A clinical trial with topical application of CBG serum showed a significant improvement in transepidermal water loss and a reduction in skin redness induced by sodium lauryl sulfate (SLS) (MDPI). These studies show a growing interest in CBG as a potential therapeutic compound, with applications in the treatment of inflammation, pain, obesity, bacterial infections, and skin conditions.Discover all products with CBG
- Effects and Benefits of CBG Like other cannabinoids,CBG has a wide range of properties.
- The most promising are its anti-tumor, anti-inflammatory, therapeutic, and antibacterial properties. With this enormous potential, CBG can be used to alleviate several conditions.Bacterial Infections
Bacterial infections are mostly benign. However, when left untreated, complications can arise. For this purpose, CBG would be indicated. It is believed to have the ability to eliminate resistant bacteria.
Glaucoma
Glaucoma is an eye disease, known to be the leading cause of blindness. For patients suffering from this disease, the research being conducted is quite promising. CBG may have the ability to reduce pressure in the eye, thus preventing damage to the sciatic nerve. InflammationCBG shares anti-inflammatory properties with CBD. These properties make it effective in treating inflammation of the skin and internal organs. Even better, CBG appears to be exceptionally effective in calming intestinal inflammation.
What is CBN (Cannabinol)?
Cannabinol, also known as CBN, was the first cannabinoid to be studied. Discovered in the late 1800s, this cannabinoid was first synthesized with remarkable success in 1940. While most other cannabinoids occur naturally in hemp plants, this is not the case for CBN. Instead, cannabinol is obtained through the breakdown of THC. This occurs particularly when cannabis plants are subjected to intense heat.
Furthermore, cannabinol is believed to possess some psychoactive properties. Although these are negligible compared to those of THC, they are what distinguishes CBN from other cannabinoids. Similarly, in combination with sleep-inducing plants, CBN is said to have a very intense sedative effect. This is why it is highly valued by insomniacs. Finally, CBN has other interesting properties.
It is said to be effective for bone growth, pain relief, inflammation reduction, and immunosuppression.
Discover all products with CBN Properties and effects of CBN
Numerous studies have been conducted on the potential benefits of CBN. And like CBD and CBG, this cannabinoid is effective in treating a multitude of conditions.
CBN has proven very effective in relieving pain, especially muscular pain. It also inhibits muscle relaxation. This makes it a very beneficial product for treating fibromyalgia, for example. Finally, when combined with CBD and THC, its effectiveness is even greater.
Osteoporosis
CBN has shown promise in the treatment of osteoporosis. It may promote the regeneration and growth of bone cells. These actions facilitate the healing of fractures and bone-related diseases such as arthritis.
Inflammation
Like its predecessors, CBN possesses anti-inflammatory properties.
Recent Studies on CBN
Here are some recent studies and their findings on the effects and therapeutic applications of CBN:
- Effects on Sleep A randomized, placebo-controlled study examined the effects of CBN alone and in combination with CBD on sleep quality. The results showed that CBN could prolong sleep time in mice. Participants who took CBN alone experienced little effect on sleepiness, but those who took CBN combined with THC reported increased sleepiness. This study suggests that CBN, especially in combination with other cannabinoids, may help improve sleep, although more research is needed to confirm these effects in humans (Sleep Foundation) (Psychology Today).Analgesic and Anti-inflammatory PropertiesCBN has shown analgesic capabilities by influencing the activity of neurons sensitive to capsaicin, a component of chili peppers that is used in many topical pain relievers. In addition, like CBD, CBN possesses anti-inflammatory properties, making it promising for the treatment of inflammatory conditions (Psychology Today).Antibacterial Properties
- One study found that CBN has the ability to fight bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). CBN not only prevented the formation of bacterial biofilms, but it also killed MRSA bacteria, making it a potential alternative to traditional antibiotics, especially against drug-resistant infections (Psychology Today). Appetite StimulationUnlike CBD, which has appetite-suppressant effects, CBN appears to stimulate appetite. This could make CBN useful for people who have difficulty maintaining their appetite due to illness or medical treatment, such as cancer (Psychology Today).Glaucoma Treatment
- Studies have shown that CBN, like other cannabinoids, may be effective in treating glaucoma by reducing intraocular pressure, which helps prevent damage to the optic nerve (Psychology Today). These studies highlight a growing interest in CBN as a potential therapeutic compound with applications in treating pain, inflammation, bacterial infections, sleep disorders, and glaucoma. However, it is important to note that while the results are promising, more research is needed to better understand the effects of CBN and confirm its efficacy and safety for various medical applications.CBD vs. CBG: What You Need to KnowCBD and CBG
- From a scientific perspective, these two cannabinoids deserve a comparative evaluation. They share interesting similarities and differences. Similarities
- Both CBD and CBG can relieve pain. Similarly, these two cannabis derivatives have been shown to have antidepressant properties. Therefore, they are popular with patients seeking relief from anxiety and stress. Both cannabinoids also show promise in promoting better sleep quality. Specifically, they may help prevent sleep disorders, particularly insomnia. Regarding their similarities, both compounds are derived from cannabigerolic acid (CBGA).
They are produced when CBGA is exposed to light or heat. Finally, both cannabinoids appear to have similar side effects. While these are generally mild, they are commonly observed in regular users. These effects are primarily dry mouth and drowsiness. Although uncommon, diarrhea is another potential side effect of CBD and CBG.
The Differences The first difference is that CBG is present in a much lower percentage in the hemp plant than CBD. Therefore, synthesizing CBG is more difficult and expensive. This is why there are far more products containing cannabidiol than those containing cannabigerol. Other differences between these two substances largely stem from the fact that CBG and CBD stimulate different parts of the endocannabinoid system.CBD primarily interacts with TVRP1 receptors. These receptors are responsible for regulating pain perception, body temperature, and tissue inflammation. CBG, on the other hand, primarily interacts with CB1 and CB2 receptors, which are more involved in regulating the nervous and immune systems. This is what appears to allow CBG to alleviate neuropathic disorders such as Huntington’s disease.
CBN vs. CBD: An In-Depth Comparison
CBN and CBD share many properties. However, the fact that CBD is much easier to extract has made it more prominent than CBN among cannabinoid-based remedies. Here are some of the other differences and similarities between these two substances. SimilaritiesCBN and CBD both share undeniable common traits. These two compounds are derived from the same plant using the same extraction method. Indeed, to obtain CBN or CBD, the hemp must first be dried and aged. Regarding their applications, both substances have proven effective in relieving pain and inflammation. Furthermore, professionals believe that the judicious use of these products could reduce reliance on traditional medications.
Finally, and most importantly, these two cannabinoids do not produce the euphoric state associated with THC. This is what gives them their enviable reputation.
The Differences
In terms of differences, CBD appears easier to extract than CBN. In fact, the latter, being less abundant in the plant, creates greater difficulty during extraction. Similarly, the range of medical uses for CBD is broader than that of CBN. This is due to the fact that CBD has been extensively studied, unlike CBN. Research has shown that CBD promotes bone regeneration, making it a recommended product for people suffering from osteoporosis.
Furthermore, it shows significant potential in the treatment of epileptic seizures. Finally, studies conducted so far do not highlight the side effects of CBN. On the other hand, CBD is known for its side effects, although they are generally mild.
CBG vs. CBN: What you need to know
Unlike their counterpart, CBD,
CBG
and CBN have not generated immense excitement within the scientific community. Similarities
The first similarity between CBG and CBN lies in their concentration in the hemp plant. These two cannabinoids are much less abundant than CBD. Consequently, their distillation is more expensive. This is why the available data is relatively limited. Similarly, CBG and CBN share almost identical therapeutic potential. More specifically, both substances show promising potential for pain relief, especially when combined with other cannabinoids. Both substances may also be able to reduce inflammation. Finally, CBG and CBN share the fact that neither has been the subject of in-depth studies in a controlled setting. This lack of scientific interest is largely due to the fact that both cannabinoids are more complex and expensive to extract than cannabidiol.
Differences
The main differences between CBG and CBN relate to the conditions they can potentially help treat and the side effects observed with regular use. CBG has shown promise in treating various brain disorders, including Huntington’s disease. It has also demonstrated potential antibacterial properties, particularly against microorganisms resistant to conventional antibiotics. Finally, CBG may provide some relief from the uncomfortable effects of glaucoma. Cannabinol, on the other hand, does not possess these properties. In contrast, CBN has the potential to promote bone growth, especially in patients suffering from the effects of aging and osteoporosis. CBN is also more appealing than CBG as a sedative, especially when combined with other cannabinoids such as THC and CBD. CBN vs. CBD vs. CBG: All Together Now
From a scientific perspective, these three compounds appear to bind to different parts of the endocannabinoid system. CBN, in particular, presents a higher risk than the other two of triggering a psychoactive reaction. CBD, on the other hand, has a wider range of medical applications. This is partly due to the fact that CBD has generated considerable interest and, consequently, a greater amount of research.
Upon closer examination of CBN, scientists believe it would be more effective for pain relief, especially for those suffering from osteoporosis and arthritis. Furthermore, this substance may reduce pain-related insomnia. CBD, on the other hand, is better suited for those seeking relaxation and calmness. Finally, of the three compounds, CBG is thought to be ideal for individuals with neurological disorders. It may also help alleviate the discomfort and pain associated with glaucoma. Unlike the other two, CBG is the only cannabinoid whose antibacterial properties counteract the effects of antibiotic-resistant microbes.
Studies on the simultaneous use of CBN, CBD, and CBG
Combined effects of CBD and CBG
Several studies suggest that the combined use of CBD and CBG may be more effective than using either cannabinoid individually. CBD is known for its calming and anti-inflammatory properties, while CBG is valued for its energizing effects and pain-relieving capabilities. Together, these cannabinoids can offer an overall relaxation effect on the body and mind, which can be beneficial for managing pain, inflammation, anxiety, and stress. The entourage effect, where cannabis compounds act synergistically, is often cited to explain these enhanced benefits. (Natural Ways CBD |
) (Evn
)
Interaction of cannabinoids with the endocannabinoid system
- CBD and CBG interact with the endocannabinoid system in different ways. CBD modulates the production of endocannabinoids naturally produced by the body, while CBG binds directly to CB1 and CB2 receptors, thus influencing the regulation of pain and inflammation. Combining these two cannabinoids can therefore balance their respective effects, enhancing their overall efficacy. (The CBDistillery) (CBD Glass Dispenser) Combined Effects of CBD, CBG, and CBNWhile specific research on the simultaneous use of CBD, CBG, and CBN is limited, anecdotal evidence and some preliminary studies suggest that this combination may offer significant therapeutic benefits. For example, CBN is known for its mild sedative properties and is often used to improve sleep. Combined with CBD and CBG, it can not only help with relaxation and pain reduction, but also improve sleep quality by reducing pain that disrupts rest (CBD.market). Specific Studies and Results
- One study found that combining CBG and CBD in full-spectrum products (which also include trace amounts of THC and other cannabinoids) maximizes the beneficial effects of each component through the entourage effect. These products are particularly effective at reducing pain and inflammation, and improving users’ overall well-being (The CBDistillery). Another study showed that mixing CBN with other cannabinoids, such as CBD, could enhance CBN’s sedative effects, making it useful for people suffering from insomnia or pain-related sleep disorders (CBD Glass Dispenser).ConclusionThe combined use of CBD, CBG, and CBN may offer broad therapeutic benefits, particularly for managing pain, inflammation, anxiety, and sleep disorders. The entourage effect, resulting from the interaction of multiple cannabinoids, maximizes the individual benefits of each component, thus providing a more comprehensive solution for various health issues. However, further research is needed to better understand the specific interactions and optimize dosages for diverse therapeutic applications.
