Caryophyllene is a component belonging to the terpene family. In fact, it's closely related to humulene , which we discussed in a previous article. As we continue our exploration of terpenes, we'll focus on this one. What does science say about it? What are its benefits for CBD product users ? Let's delve into this further below.
Science talks about caryophyllene
As always, let's begin by examining caryophyllene from a scientific perspective. So, what does science say about this terpene?
Introducing caryophyllene
Indeed, science also calls it β-caryophyllene. So, if you come across this other term somewhere, know that it refers to the same thing. Furthermore, she adds that this terpene is very similar to humulene, as we stated earlier. Along these lines, she specifies that caryophyllene is a naturally occurring bicyclic sesquiterpene composed of a 9-carbon macrocycle fused to a cyclobutane ring.
In short, it's a natural terpene composed of large nine-carbon rings. It's found in many plants such as hops, hemp, rosemary, and cloves. What about its uses? Science suggests that this terpene is widely used in the production of oils , particularly those produced by the clove tree and certain hemp oils.
Caryophyllene and our body
Let's now try to understand how this terpene works with our bodies. In fact, according to science, this compound tends to act like its cousins, the cannabinoids. How can this be explained? It interacts with the endocannabinoid system (ECS). For those unfamiliar, the ECS refers to a network or set of receptors present in various organs of the body. The best-known receptors are CB1 and CB2. That said, caryophyllene does not bind to CB1. However, it interacts with CB2. This allows it to exert its anti-inflammatory effect within the body.
Caryophyllene for CBD product consumers
Given that we have already highlighted the scientific perspective of terpenes, let us return to a point that may well interest consumers of CBD products.
Aromatic appeal
Let's start with what most terpenes have in common: a unique taste and smell. In fact, its aromas are similar to those of pepper, spices, and cloves. So, if you've ever used any of the aforementioned ingredients, you'll easily recognize this terpene. Especially since it's generally present in large quantities in plants, its aromas tend to be more prominent than others.
Therapeutic benefit
Indeed, the components present in the hemp/cannabis plant are rarely devoid of therapeutic properties. In this regard, our current terpene is no exception. In fact, it is believed to have antioxidant, neuroprotective, antimicrobial, gastroprotective, anticonvulsant, analgesic, and anti-inflammatory effects. Furthermore, it could also be useful in treating alcoholism. Let's therefore examine some related research and studies.
- study animal published in the journal Physiology & Behavior highlights the possibility that this terpene could help alleviate anxiety and depression. Researchers conducted tests on mice, which measure mental distress, anxiety, and depression. The results showed that administering caryophyllene reduced levels of anxiety, depression, and compulsive behaviors. They attribute this result to the fact that, as mentioned earlier, the terpene binds to the CB2 receptor, which is closely linked to anxiety and depression.
- Research published in the journal Pharmacology Biochemistry and Behavior explores the possibility that this compound could help in the context of alcoholism. In fact, the biggest challenge in these cases is generally breaking the vicious cycle of alcohol addiction. This research suggests that CB2 receptors in the brain could be useful in this fight. To test this, researchers conducted tests on rodents. They gave the mice alcohol to drink and then injected them with caryophyllene. They subsequently discovered that the rodents voluntarily reduced their alcohol consumption. To be more certain, they administered CB2 receptor blockers to see if the mice changed their behavior. Indeed, they resumed drinking alcohol. The researchers concluded that this terpene could be used to treat alcoholism.
- A study published in the journal European Neuropsychopharmacology in 2014 focuses on the anti-inflammatory, analgesic, and neuroprotective effects of caryophyllene. Specifically, it shows that this terpene could reduce inflammation in the terminal phase of pain. Furthermore, the study highlights that, in the case of neuropathic pain, caryophyllene reduces the heat caused by temperature and neuroinflammation of the spine.
- A study published in Epilepsy & Behavior explains that a dose of this terpene reduced seizures in mice. Therefore, this anticonvulsant property could potentially be used in humans.
Also check out our article on humulene terpenes
References
- https://fr.wikipedia.org/wiki/Caryophyll%C3%A8ne
- https://www.cibdol.fr/encyclopedie-du-cbd/qu-est-ce-que-le-caryophyll%C3%A8ne
- https://www.ncbi.nlm.nih.gov/pubmed/24930711
- https://www.sciencedirect.com/science/article/pii/S0091305714001956
- https://www.sciencedirect.com/science/article/pii/S1525505015006952
Editor-in-Chief specializing in CBD
Julien, born on July 17, 1978, in the Paris region, is a prominent writer and expert in the field of CBD products. Following his studies, Julien developed a passion for natural remedies, including CBD. In 2022, he joined the CBD.fr team as an expert and regular contributor. Thanks to his scientific expertise and clear writing style, Julien helps demystify the complexities of CBD, while highlighting its benefits and potential applications through his articles and conference presentations.
