Understanding nerolidol

*Nerolidol is among the long list of terpenes found in plants in general, and in cannabis in particular. That being said, we invite you to discover it in this article. More details below. Nerolidol in brief Let’s begin by exploring this terpene in its entirety. Specifically, we will focus on the following aspects: the name and characteristics of nerolidol.

Firstly, it should be noted that this terpene is also called peruviol. This is precisely what our source emphasizes when defining it: Nerolidol, also known as peruviol, is a sesquiterpene alcohol present in many essential oils and plants. It is a major constituent of the essential oils of neroli, Brassavola nodosa, and Myrocarpus fastigiatus, and is also found in ginger, lavender, Melaleuca, cultivated hemp (Cannabis sativa L.), and lemongrass.

As the previous quote indicates, this terpene belongs to the large sesquiterpene family. From this perspective, you might wonder what this family is. To answer your question, let’s turn to this other source: Sesquiterpenes form a class of molecules in the terpene family, with the molecular formula C15H24. Sesquiterpenoids are their numerous derivatives produced by synthesis or biological modification (typically oxidation or rearrangement). These molecules are commonly found in living organisms (especially plants), where they are synthesized from farnesyl pyrophosphate and play various metabolic roles. On the other hand, let’s look at the unique characteristic of this terpene. In fact, it’s not very different from that of others. Why? Because it relates to aroma. Specifically, nerolidol It has a strong and pleasant odor. From this perspective, it imparts woody, floral, fruity, and earthy aromas to the plants that contain it. This is the case for the following:hemp/cannabis

lemongrass, eucalyptus, tea tree, ginger, etc. Chemical and Physical PropertiesLike any other terpene, this one has physicochemical characteristics that allow for its identification. Let’s look at them below. Structure In chemistry, it is represented by the following structure. Credit: WikipediaIdentificationThe following elements allow for its identification.

IUPAC Name:

3,7,11-trimethyldodeca-1,6,10-triene-3-ol No. CAS: 7212-44-4 3790-78-1 (racemic cis) 40716-66-3 (racemic trans) 142-50-7 ((S)-Z-nerolidol)_No.ECHA: 100.027.816_No.EC: 230-597-5 No. RTECS: JR4977000

PubChem: 5284507 Appearance: Colorless to pale yellow liquid Chemical Properties These are as follows.

Chemical formula: C

15

H

26

Molar mass: 222.3663 ± 0.0141 g/mol

C 81.02%, H 11.79%, O 7.2%

1. Physical properties These are as follows:
2. Boiling point: 145-146 °C at 16 hPa^{114 °C at 1 mmHg} Density: 0.88 g·cm⁻³ 0.875 g·cm⁻³at 25 °C 3Optical propertiesIndeed, here we are dealing with the following refractive index:textit{n}_{D}^{20}
3. = 1.479³ Uses of
4. nerolidol^{In fact, after the brief presentation of this terpene, it would be interesting to focus on its uses. This refers to its areas of application and effects. That said, we have identified three major sectors that use this terpene.}
5. First, the cosmetics industry. Why? Because its unique scent is used in the manufacture of shampoos, perfumes, and many cleaning products. It is estimated that this industry uses between 10 and 100 tons of this terpene annually.^{Next, the food industry. Indeed, this was already obvious, at least to those with some knowledge of the subject. This terpene is also used in food products. From this perspective, nerolidol is a safe food flavoring agent; it acts as a flavor enhancer.}
6. Finally, the pharmaceutical industry. This is becoming increasingly clear! As soon as cannabis is mentioned, the medical applications of the substance under study are automatically discussed. Our terpene is no exception to this tradition; it is believed to be responsible for a number of effects. These are listed below.

Neuroprotective (An animal study* discusses this)

Anti-inflammatory (This research** published in the journal Clinical Pharmacology

• mentions this)_{Anti-ulcer (This 2014 study*** discusses this)}Antioxidant (Cellular studies*** focus on this effect)_{Antitumor (A study***** published in the journal Carcinogenesis}focused on this topic)
• Antinociceptive (This research****** published in the journal Clinical Pharmacology is part of this trend)

To complete this information, note that this terpene,

nerolidol,

• is naturally present in^{CBD flowers Also read about} CBD

Linalool

Terpinolene Terpenes^{References :}

*link.springer.com/article/10.1007/s11064-013-1092-2 **onlinelibrary.wiley.com/doi/abs/10.1111/fcp.12166

***degruyter.com/view/j/znc.2007.62.issue-7-8/znc-2007-7-812/znc-2007-7-812.xml

****researchgate.net/ publication/301715588_Nerolidol_A_Sesquiterpene_Alcohol_with_Multi-Faceted_Pharmacological_and_Biological_Activities

*****ncbi.nlm.nih.gov/pubmed/1988176 ******onlinelibrary.wiley.com/doi/abs/10.1111/fcp.12166