Caryophyllene is a component belonging to the terpene category. In fact, it is closely related to humulene, which we discussed in a previous article. As we continue our exploration of terpenes, we’ll focus on this one. What does science say about it? What are its benefits for consumers of CBD products? Let’s delve into this further below. Science Speaks About Caryophyllene As always, let’s begin by examining caryophyllene from a scientific perspective. So, what does science say about this terpene? Introducing CaryophylleneIndeed, science also refers to it as β-caryophyllene. So, if you encounter this other term, know that it is the same thing. Furthermore, it adds that this terpene is very similar to humulene, as we mentioned earlier. In this vein, it states that caryophyllene is a naturally occurring bicyclic sesquiterpene composed of a nine-carbon macrocycle fused to a cyclobutane ring. In simpler terms, it’s a natural terpene composed of large nine-carbon rings. It is found in many plants such as hops, hemp, rosemary, and clove. What about its uses? Science suggests that this terpene is widely used in the production of essential oils, particularly those produced by the clove tree and certain hemp oils.
Caryophyllene and Our Bodies Let’s now try to understand how this terpene interacts with our bodies. According to science, this compound tends to act similarly to its cousins, the cannabinoids. How can this be explained? It interacts with the endocannabinoid system. (ECS). From this perspective, for your information, the ECS refers to a network or set of receptors present in various organs of the body. The best-known receptors are CB1 and CB2. That being said, caryophyllene does not bind to CB1. However, it interacts with CB2. This allows it to exert its anti-inflammatory effect within the body.
Caryophyllene for CBD Product Users
Since we have already highlighted the scientific perspective of this terpene, let’s return to a point that could be of great interest to CBD product users. The Aromatic AppealLet’s start with this characteristic that most terpenes have in common. Indeed, this component has a unique taste and smell. In fact, its aromas are similar to those of pepper, spices, and cloves. So, if you have ever used any of the aforementioned ingredients, you will find it very easy to identify this terpene. Especially since it is generally present in large quantities in the plants. Therefore, its aromas tend to dominate others.
Therapeutic Interest
Indeed, the components present in the hemp/cannabis plant are rarely devoid of therapeutic properties. In this regard, our current terpene is no exception. In fact, it is said to have antioxidant, neuroprotective, antimicrobial, gastroprotective, anticonvulsant, analgesic, and anti-inflammatory effects. Furthermore, it could also be useful in treating alcoholism. Let’s review some related research/studies. An animal study published in the journal Physiology & Behavior highlights the fact that this terpene could help relieve anxiety and depression. Indeed, researchers conducted tests on mice, which measure mental distress, anxiety, and depression. The results show that administration of Caryophyllene may reduce levels of anxiety, depression, and compulsive behaviors. Researchers attribute this to the fact that, as mentioned earlier, the terpene binds to the CB2 receptor, which is closely linked to anxiety and depression. Research published in the journal *Pharmacology Biochemistry and Behavior* explores the possibility that this compound could help with alcoholism. In fact, the biggest challenge in these cases is usually breaking the vicious cycle of alcohol addiction. This research suggests that CB2 receptors in the brain could be useful in this fight. To test this, researchers conducted tests on rodents. They gave the mice alcohol to drink and then injected them with caryophyllene. They subsequently discovered that the rodents voluntarily reduced their alcohol consumption. To further confirm this, they administered CB2 receptor blockers. The question was whether the mice changed their behavior. Indeed, they started drinking alcohol again. The researchers concluded that this terpene could be used to treat alcoholism.
A study published in the journal *European Neuropsychopharmacology* in 2014 focused on its anti-inflammatory, analgesic, and neuroprotective effects. It showed that this terpene could reduce inflammation in the terminal phase. Furthermore, it highlighted that, with regard to neuropathic pain, caryophyllene reduced the heat caused by temperature and neuroinflammation of the spinal cord.
A study published in *Epilepsy & Behavior* explained that a dose of this terpene reduced seizures in mice. Therefore, this anticonvulsant property could be used in humans.
Also, see our article on the terpene humulene.
- References https://fr.wikipedia.org/wiki/Caryophyll%C3%A8ne https://www.cibdol.fr/encyclopedie-du-cbd/qu-est-ce-que-le-caryophyll%C3%A8ne https://www.ncbi.nlm.nih.gov/pubmed/24930711 https://www.sciencedirect.com/science/article/pii/S0091305714001956
- https://www.sciencedirect.com/science/article/pii/S1525505015006952
