Cannabinoids and the skin: a focus on absorption

Les cannabinoïdes et la peau : focus sur l'absorption

Research on cannabinoids is progressing. New cannabinoids are being discovered and used in various sectors, including food and cosmetics. Regarding the latter, one question remains: can cannabinoids be absorbed through the skin? Let’s explore this in detail below! Table of Contents Cannabinoids: Methods of Application to the Skin Benefits of Cannabinoids for Dermatological Disorders

Cannabinoids: Methods of Application to the Skin

First, there’s topical application. What is it? This is the method used for products like creams, ointments, and other cosmetics designed to be massaged into the epidermis (the upper layers of the skin). As you might have guessed, with this method, the cannabinoids remain on the surface. In other words, they are neither absorbed into the bloodstream nor into the dermis below.

Second, there’s transdermal application.What are we referring to? This is the other application method, which is the complete opposite of the previous one (above). Here, the cannabinoids are delivered in a way that allows them to penetrate the upper layers of the skin and reach the bloodstream. The products typically used with this method are gels. Studies* show that CBD, when administered via a transdermal gel, easily enters the bloodstream and increases plasma levels of the cannabinoid. Similarly, THC appears to behave the same way. At least, that’s what this article**** suggests. According to this article, the transdermal application of delta-8-THC (a more stable form than delta-9-THC) provides better delivery of the cannabinoid into the bloodstream within 24 hours. Based on the above, cannabinoids can be absorbed through the skin, specifically through transdermal application. While research in this area is relatively scarce, it remains a good way to bypass the digestive system and deliver cannabinoids directly into the bloodstream. Since we’re discussing skin, it would be interesting to focus on the benefits of cannabinoids in relation to certain dermatological problems.

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The Benefits of Cannabinoids for Dermatological Disorders Indeed, given the long list of cannabinoids, we cannot address each case individually. In other words, we cannot examine these molecules one by one to demonstrate their contribution to resolving specific dermatological issues. Instead, we will focus on two key areas: first, highlighting some research findings, and second, reviewing CBD products specifically designed for this type of problem. In fact, many studies focus on the effects of cannabinoids on various dermatological disorders.

To illustrate this, let’s look at a few examples. On the one hand, this study** published in theJournal of Dermatological Science. It reports on the effects of these molecules against the hyperproliferation of keratinocytes (which is associated with red, flaky, and scaly skin). Here, the immune system attacks healthy skin cells. As a result, skin cells accumulate on the skin’s surface. Along these lines, this study highlights that THC, CBN, CBD, and CBG could inhibit this keratinocyte production and help the skin regain its balance. On the other hand, this research*** published in The Journal of Clinical Investigation

. It tests the effects of CBD on human sebocytes, cells that extract excess sebum. The result? Cannabinoids may help these cells function normally by acting on TRPV4 and A2A receptors.Now that we’ve reviewed these two studies/research on the benefits of cannabinoids for dermatological conditions, let’s focus on some related products offered by CBD.FR. For more products to address certain dermatological issues, we suggest you consult our dedicated CBD cosmetics category.

References:*ncbi.nlm.nih.gov/pmc/articles/PMC6275223/ **sciencedirect.com/science/article/abs/pii/S092318110600315X ***ncbi.nlm.nih.gov/pmc/articles/PMC4151231/****sciencedirect.com/science/article/pii/037851738890052X

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( Rédacteur en chef spécialisé en CBD )
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